NOG Protein (AA 20-232)
(1 reference)-
- Target See all NOG Proteins
- NOG (Noggin (NOG))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-232
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Origin
- Mouse
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Source
- CHO Cells
- Characteristics
- ED50< 60 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Noggin (NOG) (AA 28-232) (Active) protein
NOG Origin: Human Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) proteinNOG Origin: Human Host: CHO Cells Recombinant > 95% as determined by Tris-Bis PAGE
Noggin (NOG) protein (Fc Tag)NOG Origin: Human Host: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) protein (His tag)NOG Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (His tag)NOG Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Noggin (NOG) (AA 28-232) protein (GST tag)NOG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Noggin (NOG) (AA 28-232) protein (Fc Tag)NOG Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant murine Nogginremains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Nogginshould be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).
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: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).
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- Target
- NOG (Noggin (NOG))
- Alternative Name
- Noggin (NOG Products)
- Synonyms
- SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein
- Background
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Noggin, also known as NOG, is a homodimeric glycoprotein that binds to and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors.Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients that regulate cellular responses in a concentration-dependent manner.
Synonyms: NOG - Molecular Weight
- 29-31 kDa, observed by reducing SDS-PAGE.
- UniProt
- P97466
- Pathways
- Stem Cell Maintenance, Tube Formation
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