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Neurotrophin 4 Protein (NTF4) (AA 80-209)

NTF4 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGEanalysis. Active
Catalog No. ABIN2018283
  • Target See all Neurotrophin 4 (NTF4) Proteins
    Neurotrophin 4 (NTF4)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 80-209
    Origin
    • 7
    • 3
    • 2
    • 1
    Mouse
    Source
    • 8
    • 2
    • 2
    Escherichia coli (E. coli)
    Characteristics
    ED50 <1 μg/mL, measured by a cell proliferation assay usingC6cells, corresponding to a specific activity of>1× 10^3 units/mg.
    AA 80-209, expressed with an N-terminal Met.
    Purity
    > 95 % by SDS-PAGEanalysis.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product NTF4 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in 50 mM acetic acid or ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against 50 mM acetic acid.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant mouse Neurotrophin-4 (rmNT-4) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmNT-4 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Expiry Date
    6 months
  • Target
    Neurotrophin 4 (NTF4)
    Alternative Name
    Neurotrophin-4 (NT-4) (NTF4 Products)
    Synonyms
    NTF5 Protein, GLC10 Protein, GLC1O Protein, NT-4 Protein, NT-4/5 Protein, NT-5 Protein, NT4 Protein, NT5 Protein, NT4P Protein, Ntf5 Protein, 2900040K06Rik Protein, AI462899 Protein, NT4/5 Protein, Ntf-5 Protein, Ntf4 Protein, neurotrophin 4 Protein, neurotrophin 5 Protein, NTF4 Protein, Ntf4 Protein, ntf4 Protein, Ntf5 Protein
    Background
    Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals . In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NF-kappaB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer's.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0 kDaanalyzed by reducing SDS-PAGE.
    Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)
    Molecular Weight
    14.0 kDa, observed by reducing SDS-PAGE.
    UniProt
    Q80VU4
    Pathways
    RTK Signaling
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