IL-3 Protein (AA 20-152)
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- Target See all IL-3 Proteins
- IL-3 (Interleukin 3 (IL-3))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-152
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Origin
- Human
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Source
- CHO Cells
- Characteristics
- ED50 < 0.1 ng/mL, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1x10^7 units/mg.
- Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL-3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human Interlerkin 3 (IL-3) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-3 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- IL-3 (Interleukin 3 (IL-3))
- Abstract
- IL-3 Products
- Synonyms
- BPA Protein, Csfmu Protein, HCGF Protein, Il-3 Protein, MCGF Protein, PSF Protein, IL-3 Protein, MULTI-CSF Protein, interleukin 3 Protein, interleukin 3 (colony-stimulating factor, multiple) Protein, Il3 Protein, IL3 Protein
- Background
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Interleukin-3 (IL-3) is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine.Recombinant human interleukin 3 expressed in CHO cells is glycosylated protein with molecular weight range from 17 to 30 kDa shown in non-reducing SDS-PAGE.
Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor - Molecular Weight
- 17-30 kDa, observed by non-reducing SDS-PAGE.
- UniProt
- Q6GS87
- Pathways
- JAK-STAT Signaling, Regulation of Carbohydrate Metabolic Process, Autophagy
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