IGFBP4 Protein (AA 22-258) (His tag)
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- Target See all IGFBP4 Proteins
- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 22-258
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Origin
- Human
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Source
- HEK-293T Cells
- Purification tag / Conjugate
- This IGFBP4 protein is labelled with His tag.
- Characteristics
- ED50 < 50 ng/mL, measured in a bioassay using FDC-P1 cells in the presence of 15 ng/mL human IGF-II.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IGFBP4 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human IGF-BP-4 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human IGF-BP-4, His should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
- Alternative Name
- Insulin-Like Growth Factor-Binding Protein 4 (IGF-BP-4) (IGFBP4 Products)
- Synonyms
- IGFBP4 Protein, igfbp4 Protein, BP-4 Protein, HT29-IGFBP Protein, IBP4 Protein, IGFBP-4 Protein, AI875747 Protein, Deb2 Protein, IGF-BP4 Protein, IBP-4 Protein, insulin like growth factor binding protein 4 Protein, insulin-like growth factor-binding protein 4 Protein, insulin-like growth factor binding protein 4 Protein, IGFBP4 Protein, LOC100136305 Protein, LOC100194498 Protein, igfbp4 Protein, Igfbp4 Protein
- Background
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Insulin-like growth factor-binding protein 4 (IGF-BP-4), also known as IBP-4, is a secreted glycoprotein belonging to the IGFBP family. IGF-BP-4 is produced by osteoblasts, epidermis, ovarian follicles and other tissues. It binds both insulin-like growth factor (IGF) I and II, and it circulates in the plasma in both glycosylated and non-glycosylated forms. IGF-BP-4 prolongs the half-life of the IGFs and has been shown to inhibit or stimulate the growth-promoting effects of the IGFs. Pregnancy Associated Plasma Protein A (PAPP-A) proteolytically cleaves IGF-BP-4 and reduces its affinity to bind IGFs, and thus serves as an important regulator of IGF-BP-4 function.
Synonyms: Insulin-like Growth Factor-Binding Protein 4, IBP-4, HT29-IGF-BP, colon cancer cell growth inhibitor - Molecular Weight
- 30-35 kDa, observed by reducing SDS-PAGE.
- UniProt
- P22692
- Pathways
- WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
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