IL1RN Protein (AA 26-177)
-
- Target See all IL1RN Proteins
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 26-177
-
Origin
- Human
-
Source
- HEK-293T Cells
- Characteristics
- ED50 < 0.1 μg /mL, measured in a neutralization assay using D10S cells in the presence of 50pg/mL Human IL-1a.
- Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL1RN Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human IL-1 Receptor Antagonist remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IL-1 Receptor Antagonist should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
-
- Target
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- Alternative Name
- IL-1 Receptor Antagonist (IL1RN Products)
- Synonyms
- DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein
- Background
-
IL-1 Receptor Antagonist, also known as IL-1RA, ICIL-1RA, IRAP and IL-1RN, is a member of the interleukin 1 cytokine family. It is expressed by monocytes, neutrophils, macrophages, epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
Synonyms: IL-1RA, ICIL-1RA, IRAP, IL-1RN - Molecular Weight
- 18-23 kDa, observed by reducing SDS-PAGE.
- UniProt
- P18510
- Pathways
- NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
-