IFNGR2 Protein (AA 28-247)

Catalog No. ABIN2017971

Product Details

Target: IFNGR2 (Interferon gamma Receptor 2 (Interferon gamma Transducer 1) (IFNGR2))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 28-247

Origin: Human

Source: CHO Cells

Characteristics: ED50 < 0.1 μg/mL, measured in a cell cytotoxicity assay using HT-29 (HTB-38) cells in the presence of 1 ng/mL human IFN-gamma.

Purity: > 95 % as analyzed by SDS-PAGE.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant Human IFN-gamma Receptor II remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IFN-gamma Receptor II should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: IFNGR2 (Interferon gamma Receptor 2 (Interferon gamma Transducer 1) (IFNGR2))

Abstract: IFNGR2 Products

Synonyms: Ifgr2 Protein, Ifgt Protein, AF-1 Protein, IFGR2 Protein, IFNGT1 Protein, interferon gamma receptor 2 Protein, Ifngr2 Protein, IFNGR2 Protein, LOC487739 Protein

Background: IFN-gamma Receptor II, also known as IFNGR2 and IFNGT1, is a transmembrane protein belonging to the type II cytokine receptor family. IFNGR2 is a non-ligand-binding beta chain of the IFN-gamma receptor. It is an integral part of the IFN-gamma signaling transduction pathway and is likely to interact with GAF, JAK1 and JAK2. Defects in IFNGR2 are a cause of autosomal recessive Mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.
Synonyms: IFNGR2, IFNGT1

Molecular Weight: 38-40 kDa, observed by reducing SDS-PAGE.

UniProt: P38484