GMFB Protein (AA 1-142)
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- Target See all GMFB products
- GMFB (Glia Maturation Factor, beta (GMFB))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-142
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purity
- > 95 % by SDS-PAGE and HPLC analyses.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Glia Maturation Factor, beta (GMFB) (Active) protein
GMFB Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Glia Maturation Factor, beta (GMFB) (AA 1-154) protein (GST tag)GMFB Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Glia Maturation Factor, beta (GMFB) (AA 1-142) protein (His tag)GMFB Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Glia Maturation Factor, beta (GMFB) protein (Myc-DYKDDDDK Tag)GMFB Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human Glia Maturation Factor beta (rhGMF-beta) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhGMF-beta remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- GMFB (Glia Maturation Factor, beta (GMFB))
- Alternative Name
- Glia Maturation Factor beta (GMF-Beta) (GMFB Products)
- Synonyms
- fc25b01 Protein, zgc:56451 Protein, zgc:86831 Protein, wu:fa97c03 Protein, wu:fc25b01 Protein, GMFB Protein, DKFZp459J101 Protein, gmfb Protein, 3110001H22Rik Protein, 3110001O16Rik Protein, AI851627 Protein, C79176 Protein, D14Ertd630e Protein, GMF Protein, gmf-beta Protein, glia maturation factor, beta Protein, glia maturation factor beta Protein, Glia maturation factor beta Protein, glia maturation factor, beta L homeolog Protein, gmfb Protein, GMFB Protein, Gmfb Protein, EDI_093190 Protein, Tsp_04922 Protein, LOC100101176 Protein, gmfb.L Protein
- Background
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Glia Maturation Factor beta (GMF-beta) is a 17 kDa brain specific protein that belongs to the ADF/cofilin superfamily. It is a neurotrophin that induces maturation of neurons and glial cells, and. Unlike other neurotrophins, GMF-beta lacks a leader sequence and can be phosphorylated by protein kinase A and protein kinase C suggesting its role in signal transduction. GMF-beta is a prominent mediator of inflammation in the central nervous system and can activate several inflammation-related genes such as tumor necrosis factor-beta and interleukin-1beta. Researchers have shown there are significantly higher levels of GMF-beta protein in all the effected regions of Alzheimer's disease (AD) brains suggesting an important role of GMF-beta in AD pathogenesisRecombinant human Glia Maturation Factor beta (rhGMF-beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 142 amino acids. rhGMF-beta has a molecular mass of 16.7 kDa analyzed by reducing SDS-PAGE.
Synonyms: GMFB - Molecular Weight
- 16.7 kDa, observed by reducing SDS-PAGE.
- UniProt
- P60983
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