GMFB Protein (AA 1-142)

Catalog No. ABIN2017881

Product Details

Target: GMFB (Glia Maturation Factor, beta (GMFB))

Protein Type: Recombinant

Protein Characteristics: AA 1-142

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % by SDS-PAGE and HPLC analyses.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant human Glia Maturation Factor beta (rhGMF-beta) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhGMF-beta remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: GMFB (Glia Maturation Factor, beta (GMFB))

Alternative Name: Glia Maturation Factor beta (GMF-Beta) (GMFB Products)

Synonyms: fc25b01 Protein, zgc:56451 Protein, zgc:86831 Protein, wu:fa97c03 Protein, wu:fc25b01 Protein, GMFB Protein, DKFZp459J101 Protein, gmfb Protein, 3110001H22Rik Protein, 3110001O16Rik Protein, AI851627 Protein, C79176 Protein, D14Ertd630e Protein, GMF Protein, gmf-beta Protein, glia maturation factor, beta Protein, glia maturation factor beta Protein, Glia maturation factor beta Protein, glia maturation factor, beta L homeolog Protein, gmfb Protein, GMFB Protein, Gmfb Protein, EDI_093190 Protein, Tsp_04922 Protein, LOC100101176 Protein, gmfb.L Protein

Background: Glia Maturation Factor beta (GMF-beta) is a 17 kDa brain specific protein that belongs to the ADF/cofilin superfamily. It is a neurotrophin that induces maturation of neurons and glial cells, and. Unlike other neurotrophins, GMF-beta lacks a leader sequence and can be phosphorylated by protein kinase A and protein kinase C suggesting its role in signal transduction. GMF-beta is a prominent mediator of inflammation in the central nervous system and can activate several inflammation-related genes such as tumor necrosis factor-beta and interleukin-1beta. Researchers have shown there are significantly higher levels of GMF-beta protein in all the effected regions of Alzheimer's disease (AD) brains suggesting an important role of GMF-beta in AD pathogenesisRecombinant human Glia Maturation Factor beta (rhGMF-beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 142 amino acids. rhGMF-beta has a molecular mass of 16.7 kDa analyzed by reducing SDS-PAGE.
Synonyms: GMFB

Molecular Weight: 16.7 kDa, observed by reducing SDS-PAGE.

UniProt: P60983