FGF6 Protein (AA 41-208)
FGF6
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % as analyzed by SDS-PAGE and HPLC.
Active
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- Target See all FGF6 Proteins
- FGF6 (Fibroblast Growth Factor 6 (FGF6))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 41-208
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Characteristics
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ED50 < 2.5 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence 1 xg/mL heparin, corresponding to a specific activity of > 4x 10^5 units/mg.
AA 41-208, expressed with an N-terminal Met. - Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product FGF6 Protein
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Fibroblast Growth Factor 6 (FGF6) (AA 41-208) protein (His tag)
FGF6 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human Fibroblast Growth Factor-6 (rhFGF-6) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhFGF-6 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- FGF6 (Fibroblast Growth Factor 6 (FGF6))
- Alternative Name
- Fibroblast Growth Factor-6 (FGF-6) (FGF6 Products)
- Synonyms
- FGF6 Protein, hst2 Protein, fgf-6 Protein, hbgf-6 Protein, HBGF-6 Protein, HST2 Protein, Fgf-6 Protein, HSTF-2 Protein, fgf4 Protein, fgf6 Protein, fibroblast growth factor 6 Protein, fibroblast growth factor 6a Protein, FGF6 Protein, fgf6 Protein, Fgf6 Protein, fgf6a Protein
- Background
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Fibroblast Growth Factor-6 (FGF-6) is a cytokine belonging to the heparin-binding FGF family, and is structurally related to other members of FGF family, particularly FGF-4. In vivo, FGF-6 exhibits an expression profile predominantly restricted tothe myogenic lineage, and it preferentially binds to two of the FGF receptors: FGFR1 and FGFR4. FGF-6 functions in muscle regeneration, myoblast proliferation and migration, and muscle differentiation in a dose-dependent manner. In vivo high concentration of recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4, respectively, as FGFR1 promotes the proliferation while FGFR4 promotes the differentiation in the muscle. Besides its dual function in muscle regeneration, FGF-6 may act as a regulator of bone metabolism as well.Recombinant human Fibroblast Growth Factor-6 (rhFGF-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-6 has a molecular mass of 18.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: Fibroblast Growth Factor-6, HBGF-6, HST-2 - Molecular Weight
- 18.8 kDa, observed by reducing SDS-PAGE.
- UniProt
- P10767
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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