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FGF18 Protein (AA 28-199)

FGF18 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Catalog No. ABIN2017814
  • Target See all FGF18 Proteins
    FGF18 (Fibroblast Growth Factor 18 (FGF18))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 28-199
    Origin
    • 7
    • 3
    • 3
    • 1
    Rat
    Source
    • 10
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Characteristics
    ED50 < 0.5 xg/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 2x 10^3 units/mg.
    Purity
    > 95 % as analyzed by SDS-PAGE and HPLC.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product FGF18 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrFGF-18 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Expiry Date
    6 months
  • Target
    FGF18 (Fibroblast Growth Factor 18 (FGF18))
    Alternative Name
    Fibroblast Growth Factor-18 (FGF-18) (FGF18 Products)
    Synonyms
    FGF-18 Protein, ZFGF5 Protein, D130055P09Rik Protein, fgf18 Protein, FGF18 Protein, fgf18l Protein, fibroblast growth factor 18 Protein, fibroblast growth factor 18a Protein, fibroblast growth factor 18b Protein, FGF18 Protein, Fgf18 Protein, fgf18a Protein, Tsp_09844 Protein, fgf18b Protein
    Background
    Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family, which has 23 different members. Structurally, FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs, FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth, FGF-18 is expressed in perichondrium and developing joints, and regulates bone formation by inhibiting chondrocyte proliferation and differentiation, FGF-18 knock-out mice survive embryonic development, but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung, and alters the morphology of the pulmonary mesenchyma. Recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) produced in E. coli is a single non-glycosylated polypeptide chain containing of 172 amino acids. A fully biologically active molecule, rrFGF-18 has a molecular mass of 20.1 kDa analyzed by non-reducing SDS-PAGE.
    Synonyms: Fibroblast growth factor 18, FGF-18, zFGF5, Fgf18, D130055P09Rik
    Molecular Weight
    20.1 kDa, observed by non-reducing SDS-PAGE.
    UniProt
    O88182
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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