FGF16 Protein (AA 2-207)

Catalog No. ABIN2017808

Product Details

Target: FGF16 (Fibroblast Growth Factor 16 (FGF16))

Protein Type: Recombinant

Protein Characteristics: AA 2-207

Origin: Human

Source: CHO Cells

Characteristics: Measured in a cell proliferation assay using 3T3 mouse fibroblast cell, The ED50 for this effect is < 20 ng/mL.

Purity: > 95 % as analyzed by SDS-PAGE and HPLC.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant Human Fibroblast Growth Factor-16 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Fibroblast Growth Factor-16 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: FGF16 (Fibroblast Growth Factor 16 (FGF16))

Alternative Name: Fibroblast Growth Factor-16 (FGF-16) (FGF16 Products)

Synonyms: FGF16 Protein, FGF-16 Protein, fibroblast growth factor 16 Protein, FGF16 Protein, fgf16 Protein, Fgf16 Protein

Background: Fibroblast Growth Factor-16 (FGF-16) is a heparin binding growth factor, a member of the FGF family. All FGF family members are heparin binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue. FGF-16 is most similar to FGF-9 (73 % amino acid identity). The protein sequence of human FGF-16 displays 98.6 % identity with rat FGF-16. Chimpanzee FGF-16 (207 amino acids), chicken FGF-16 (207 amino acids), and zebrafish FGF-16 (203 amino acids) show 100 %, 89.9 %, and 79.2 % total amino acid identity with human FGF-16.Recombinant human FGF-16 produced in CHO cells is a polypeptide chain containing 206 amino acids. A fully biologically active molecule, rhFGF-16 has a molecular mass of 23 kDa analyzed by reducing SDS-PAGE.
Synonyms: FGF-16, Fibroblast Growth Factor-16, FGFG

Molecular Weight: 23 kDa, observed by reducing SDS-PAGE.

UniProt: O43320

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway