FGF21 Protein (AA 29-209) (His tag)
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- Target See all FGF21 Proteins
- FGF21 (Fibroblast Growth Factor 21 (FGF21))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 29-209
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Origin
- Human
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Source
- CHO Cells
- Purification tag / Conjugate
- This FGF21 protein is labelled with His tag.
- Characteristics
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ED50<0.3 μg/mL, measured in a bioassay using NIH-3T3 cells.
AA 29-209, expressed with C-terminal 6×His. - Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product FGF21 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human FGF-21 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human FGF-21, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
- Expiry Date
- 6 months
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- Target
- FGF21 (Fibroblast Growth Factor 21 (FGF21))
- Alternative Name
- FGF-21 (FGF21 Products)
- Synonyms
- FGF21 Protein, fibroblast growth factor 21 Protein, FGF21 Protein, fgf21 Protein, Fgf21 Protein
- Background
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FGF-21, also known as fibroblast growth factor-21 and FGFL, is a secreted growth factor belonging to theheparin-binding growth factor family. It is produced by hepatocytes in response to fatty acid stimulation. FGF-21 couples with its co-factor beta-Klotho to signal through FGFR1c and FGFR4. Signal transduction results in insulin-independent uptake of glucose by adipocytes. Clinical administration of FGF-21 induces energy expenditure, fat utilization and lipid excretion.
Synonyms: fibroblast growth factor-21, FGFL - Molecular Weight
- 23-25 kDa, observed by reducing SDS-PAGE.
- UniProt
- Q9NSA1
- Pathways
- RTK Signaling
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