CCL11 Protein
-
- Target See all CCL11 products
- CCL11 (Chemokine (C-C Motif) Ligand 11 (CCL11))
- Protein Type
- Recombinant
- Biological Activity
- Active
-
Origin
- Mouse
-
Source
- Escherichia coli (E. coli)
- Sequence
- HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP
- Characteristics
- Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100-1000 ng/mL.
- Purity
- > 96 % by SDS-PAGE and HPLC analyses.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- < 1 EU/μg of rMuEotaxin/CCL11 as determined by LAL method.
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
- Buffer
- Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.
-
- Target
- CCL11 (Chemokine (C-C Motif) Ligand 11 (CCL11))
- Alternative Name
- Eotaxin/CCL11 (CCL11 Products)
- Synonyms
- SCYA11 Protein, Scya11 Protein, eotaxin Protein, Eotaxin Protein, C-C motif chemokine ligand 11 Protein, chemokine (C-C motif) ligand 11 Protein, CCL11 Protein, Ccl11 Protein
- Background
-
Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.
Synonyms: Eotaxin murine, CCL11 murine - Molecular Weight
- 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
- Pathways
- Regulation of Actin Filament Polymerization, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
-