CCL8 Protein (AA 24-99) (His tag)
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- Target See all CCL8 Proteins
- CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-99
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This CCL8 protein is labelled with His tag.
- Purpose
- Recombinant Human C-C Motif Chemokine 8/CCL8/MCP-2 (C-6His)
- Sequence
- QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTQRGKE VCADPKERWV RDSMKHLDQI FQNLKPVDHH HHHH
- Characteristics
- Recombinant Human C-C Motif Chemokine 8/CCL8 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln24-Pro99) of Human CCL8 fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product CCL8 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl,1 mM EDTA, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))
- Alternative Name
- C-C Motif Chemokine 8/CCL8 (CCL8 Products)
- Synonyms
- HC14 Protein, MCP-2 Protein, MCP2 Protein, SCYA10 Protein, SCYA8 Protein, 1810063B20Rik Protein, AB023418 Protein, Mcp2 Protein, Scya8 Protein, C-C motif chemokine ligand 8 Protein, chemokine (C-C motif) ligand 8 Protein, C-C motif chemokine 8 Protein, monocyte chemoattractant protein-2 precursor Protein, CCL8 Protein, Ccl8 Protein, LOC101119572 Protein, MCP-2 Protein
- Sub Type
- Fusionprotein
- Background
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Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemoattractants. CCL8 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, which are implicated in allergic response, and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors including CCR1, CCR2B and CCR5.
Alternative Names: C-C Motif Chemokine 8, HC14, Monocyte Chemoattractant Protein 2, Monocyte Chemotactic Protein 2, MCP-2, Small-Inducible Cytokine A8, CCL8, MCP2, SCYA10, SCYA8 - Molecular Weight
- 9.95 kDa
- UniProt
- P80075
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