C-Peptide Protein
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % by HPLC & SDS-PAGE
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- Target See all C-Peptide Proteins
- C-Peptide
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purity
- > 95 % by HPLC & SDS-PAGE
- Top Product
- Discover our top product C-Peptide Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10mM PBS (pH 7.5)
- Preservative
- Without preservative
- Storage
- 4 °C
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- Target
- C-Peptide
- Abstract
- C-Peptide Products
- Synonyms
- insulin 2 Protein, Ins2 Protein
- Background
- Connecting peptide, or C-peptide, is a short 31-amino-acid protein that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. It has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes.
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