PEA15 Protein (AA 1-130)
PEA15
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by reducing SDS-PAGE.
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- Target See all PEA15 Proteins
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-130
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15
- Sequence
- GSHMAEYGTL LQDLTNNITL EDLEQLKSAC KEDIPSEKSE EITTGSAWFS FLESHNKLDK DNLSYIEHIF EISRRPDLLT MVVDYRTRVL KISEEDELDT KLTRIPSAKK YKDIIRQPSE EEIIKLAPPP KKA
- Characteristics
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala130) of Human PEA15.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product PEA15 Protein
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phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (GST tag)
PEA15 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
phosphoprotein Enriched in Astrocytes 15 (PEA15) protein (Myc-DYKDDDDK Tag)PEA15 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
- Alternative Name
- PEA15 (PEA15 Products)
- Synonyms
- HMAT1 Protein, HUMMAT1H Protein, MAT1 Protein, MAT1H Protein, PEA-15 Protein, PED Protein, Pea15a Protein, PEA15 Protein, DKFZp459O1410 Protein, proliferation and apoptosis adaptor protein 15 Protein, phosphoprotein enriched in astrocytes 15 Protein, proliferation and apoptosis adaptor protein 15 L homeolog Protein, Astrocytic phosphoprotein PEA-15 Protein, PEA15 Protein, Pea15 Protein, pea15.L Protein, pea15 Protein
- Background
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Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
Alternative Names: Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15 - Molecular Weight
- 15.3 kDa
- UniProt
- Q15121
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