CDH6 Protein (AA 22-615) (His tag)
CDH6
Origin: Human
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
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- Target See all CDH6 Proteins
- CDH6 (K-Cadherin (CDH6))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-615
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This CDH6 protein is labelled with His tag.
- Purpose
- Recombinant Human Cadherin-6/K-Cadherin/CDH6 (C-6His)
- Sequence
- TPLSKRTSGF PAKKRALELS GNSKNELNRS KRSWMWNQFF LLEEYTGSDY QYVGKLHSDQ DRGDGSLKYI LSGDGAGDLF IINENTGDIQ ATKRLDREEK PVYILRAQAI NRRTGRPVEP ESEFIIKIHD INDNEPIFTK EVYTATVPEM SDVGTFVVQV TATDADDPTY GNSAKVVYSI LQGQPYFSVE SETGIIKTAL LNMDRENREQ YQVVIQAKDM GGQMGGLSGT TTVNITLTDV NDNPPRFPQS TYQFKTPESS PPGTPIGRIK ASDADVGENA EIEYSITDGE GLDMFDVITD QETQEGIITV KKLLDFEKKK VYTLKVEASN PYVEPRFLYL GPFKDSATVR IVVEDVDEPP VFSKLAYILQ IREDAQINTT IGSVTAQDPD AARNPVKYSV DRHTDMDRIF NIDSGNGSIF TSKLLDRETL LWHNITVIAT EINNPKQSSR VPLYIKVLDV NDNAPEFAEF YETFVCEKAK ADQLIQTLHA VDKDDPYSGH QFSFSLAPEA ASGSNFTIQD NKDNTAGILT RKNGYNRHEM STYLLPVVIS DNDYPVQSST GTVTVRVCAC DHHGNMQSCH AEALIHPTGL STGAVDHHHH HH
- Characteristics
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Recombinant Human Cadherin-6/K-Cadherin/CDH6 (C-6His)
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product CDH6 Protein
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K-Cadherin (CDH6) (AA 1-663) protein (GST tag)
CDH6 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CDH6 (K-Cadherin (CDH6))
- Alternative Name
- Cadherin-6 (CDH6 Products)
- Background
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Recombinant Human Cadherin-6 produced by transfected human cells is a secreted protein with sequence (Ser54-Ala615) of Human CDH6 fused with a polyhistidine tag at the C-terminus.
Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14. - Molecular Weight
- 67.43 kDa
- UniProt
- P55285
- Pathways
- Cell-Cell Junction Organization
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