TIE1 Protein (Soluble) (His tag)
TIE1
Origin: Mouse
Host: Insect Cells
Recombinant
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- Target See all TIE1 Proteins
- TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
- Protein Type
- Recombinant
- Protein Characteristics
- Soluble
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Origin
- Mouse
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Source
- Insect Cells
- Purification tag / Conjugate
- This TIE1 protein is labelled with His tag.
- Sequence
- SVDLTLLANL RITDPQRFFL TCVSGEAGAG RSSDPPLLLE KDDRIVRTFP PGQPLYLARN GSHQVTLRGF SKPSDLVGVF SCVGGAGARR TRVLYVHNSP GAHLFPDKVT HTVNKGDTAV LSAHVHKEKQ TDVIWKNNGS YFNTLDWQEA DDGRFQLQLQ NVQPPSSGIY SATYLEASPL GSAFFRLIVR GCGAGRWGPG CVKDCPGCLH GGVCHDHDGE CVCPPGFTGT RCEQACREGR FGQSCQEQCP GTAGCRGLTF CLPDPYGCSC GSGWRGSQCQ EACAPDHFGA DCRLQCQCQN GGTCDRFSGC VCPSGWHGVH CEKSDRIPQI LSMATEVEFN IGTMPRINCA AAGNPFPVRG SMKLRKPDGT MLLSTKVIVE PDRTTAEFEV PSLTLGDSGF WECRVSTSGG QDSRRFKVNV KVPPVPLTAP RLLAKQSRQL VVSPLVSFSG DGPISSVRLH YRPQDSTIAW SAIVVDPSEN VTLMNLKPKT GYNVRVQLSR PGEGGEGGWG PSALMTTDCP EPLLQPWLES WHVEGPDRLR VSWSLPSVPL SGDGFLLRLW DGARGQERRE NISFPQARTA LLTGLTPGTH YQLDVRLYHC TLLGPASPPA HVHLPPSGPP APRHLHAQAL SDSEIQLMWQ HPEAPSGPIS KYIVEIQVAG GSGDPQWMDV DRPEETSIIV RGLNASTRYL FRVRASVQGL GDWSNTVEEA TLGNGLQSED PVRESRATRH HHHHH
- Characteristics
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Length (AA): 735
Chromosomal location: 4 D2.1, 4 50.0 cM - Top Product
- Discover our top product TIE1 Protein
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- Comment
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Soluble Receptors
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- The lyophilized sTIE-1-His is soluble in water and most aqueous buffers and should be reconstituted in PBS to a concentration not lower than 50 μg/mL.
- Buffer
- PBS
- Storage
- -20 °C/-80 °C
- Storage Comment
- Lyophilized samples are stable for greater than six months at -20 °C to -70 °C. Reconstituted sTIE-1-His should be stored in working aliquots at -20 °C.
- Expiry Date
- 6 months
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- Target
- TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
- Alternative Name
- TIE-1 (TIE1 Products)
- Synonyms
- JTK14 Protein, TIE Protein, D430008P04Rik Protein, tie-1 Protein, tyrosine kinase with immunoglobulin like and EGF like domains 1 Protein, tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Protein, tyrosine-protein kinase receptor Tie-1 Protein, endothelium-specific receptor tyrosine kinase 1 Protein, TIE1 Protein, Tie1 Protein, CpipJ_CPIJ018933 Protein, tie1 Protein
- Background
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Recombinant mouse soluble TIE-1 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ser22-Ala748). Mouse sTIE-1 monomer has a calculated molecular mass of approximately 79,8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 95 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.
Synonyms: Tie1, TIE, tie-1, D430008P04Rik - NCBI Accession
- NP_035717, NM_011587
- UniProt
- Q06806
- Pathways
- RTK Signaling
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