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VEGFC Protein

VEGFC Origin: Rat Host: Insect Cells Recombinant > 90 % by SDS-PAGE Active
Catalog No. ABIN1589785
  • Target See all VEGFC Proteins
    VEGFC (Vascular Endothelial Growth Factor C (VEGFC))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 16
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    Rat
    Source
    • 10
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Insect Cells
    Purpose
    VEGF-C
    Sequence
    DTVKLAAAHY NTEILKSIDN EWRKTQCMPR EVCIDVGKEF GAATNTFFKP PCVSVYRCGG CCNSEGLQCM NTSTGYLSKT LFEITVPLSQ GPKPVTISFA NHTSCRCMSK LDVYRQVHSI IHHHHHH
    Specificity
    Chromosomal location:16p11
    Characteristics
    Length (aa):127
    Purity
    > 90 % by SDS-PAGE
    Top Product
    Discover our top product VEGFC Protein
  • Application Notes
    The biological activity was determined (i) by the ability to induce VEGFR-3/FLT-4 receptor phosphorylation in PAEC/VEGFR-3 cells and (ii) the VEGF-C-induced proliferation of primary human dermal lymphatic endothelial cells (HDLEC).
    Comment

    Cytokines & Growth Factors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    The lyophilized VEGF-C is soluble in water and most aqueous buffers. The lyophilized VEGF-C should be reconstituted in PBS or medium to a concentration not lower than 50 μg/mL.
    Buffer
    50 mM acetic acid
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted VEGF-C should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!
    Expiry Date
    6 months
  • Target
    VEGFC (Vascular Endothelial Growth Factor C (VEGFC))
    Alternative Name
    VEGF-C (VEGFC Products)
    Synonyms
    VEGFC Protein, vegf-c Protein, xvegf-c Protein, Flt4-L Protein, VRP Protein, AW228853 Protein, VEGF-C Protein, vascular endothelial growth factor c Protein, vascular endothelial growth factor C Protein, vascular endothelial growth factor C S homeolog Protein, vegfc Protein, VEGFC Protein, vegfc.S Protein, Vegfc Protein
    Background
    VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant rat VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant rat VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant rat VEGF-C contains 127 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 15-20 kDa protein in SDS-PAGE under reducing conditions.
    Synonyms: vascular endothelial growth factor C, Vegfc
    Molecular Weight
    15.0 - 20.0 kDa
    Gene ID
    114111
    NCBI Accession
    NM_053653, NP_446105
    UniProt
    O35757
    Pathways
    RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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