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Podoplanin Protein (PDPN) (Soluble) (His tag)

PDPN Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE
Catalog No. ABIN1589762
  • Target See all Podoplanin (PDPN) Proteins
    Podoplanin (PDPN)
    Protein Type
    Recombinant
    Protein Characteristics
    Soluble
    Origin
    • 12
    • 7
    • 4
    • 2
    • 1
    • 1
    Mouse
    Source
    • 11
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This Podoplanin protein is labelled with His tag.
    Purpose
    Podoplanin, soluble
    Sequence
    GTIGVNEDDI VTPGTGDGMV PPGIEDKITT TGATGGLNES TGKAPLVPTQ RERGTKPPLE ELSTSATSDH DHREHESTTT VKVVTSHSVD KKTSHPNRDN AGDETQTTDK KDGLPVVTLE HHHHHH
    Specificity
    Chromosomal location:4 E1, 4
    Characteristics
    Length (aa):126
    Purity
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product PDPN Protein
  • Comment

    Soluble Receptors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
    Buffer
    PBS
    Handling Advice
    Centrifuge vial prior to opening.
    Storage
    RT,-20 °C
    Storage Comment
    The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted sPodoplanin should be stored in working aliquots at -20°C.
  • Target
    Podoplanin (PDPN)
    Alternative Name
    Podoplanin (PDPN Products)
    Synonyms
    PDPN Protein, AGGRUS Protein, GP36 Protein, GP40 Protein, Gp38 Protein, HT1A-1 Protein, OTS8 Protein, PA2.26 Protein, T1A Protein, T1A-2 Protein, OTS-8 Protein, RANDAM-2 Protein, T1-alpha Protein, T1a Protein, T1alpha Protein, E11 Protein, RTI40 Protein, podoplanin Protein, PDPN Protein, Pdpn Protein
    Background
    Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46 % aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
    Synonyms: Pdpn, T1a, Gp38, OTS-8, T1alpha, RANDAM-2, T1-alpha
    Gene ID
    14726
    NCBI Accession
    NM_010329, NP_034459
    UniProt
    Q62011
    Pathways
    Dicarboxylic Acid Transport
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