MESP1 Protein

Catalog No. ABIN1589743

Product Details

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Protein Type: Recombinant

Origin: Human

Source: Insect Cells

Purpose: MesP1

Sequence: MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL LETWMPLSPL EWLPEEPK

Specificity: Chromosomal location:15q26.1

Characteristics: Length (aa):268

Purity: > 95 % by SDS-PAGE

Application Details

Comment:

Cytokines & Growth Factors

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.

Buffer: 0.5X PBS

Handling Advice: Freeze/thaw cycles will result in significant loss of activity.

Storage: RT,0 °C

Storage Comment: The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0°C. Freeze/thaw cycles will result in significant loss of activity.

Target Details

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Alternative Name: MesP1 (MESP1 Products)

Synonyms: bHLHc5 Protein, mesp Protein, mesp1 Protein, mespa Protein, CMESO-1 Protein, CMESO2 Protein, MESP1 Protein, mesoderm posterior 1 Protein, mesoderm posterior bHLH transcription factor 1 Protein, mesoderm posterior 1 homolog (mouse) Protein, mesoderm posterior homolog B Protein, mesoderm posterior homolog B L homeolog Protein, Mesp1 Protein, MESP1 Protein, mesp1 Protein, mespb Protein, mespb.L Protein

Background: ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms: MESP1, bHLHc5

Molecular Weight: 34 kDa

Gene ID: 55897

NCBI Accession: NM_018670, NP_061140

UniProt: Q9BRJ9

Pathways: Regulation of Muscle Cell Differentiation