IL-37 Protein (His tag)
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- Target See all IL-37 (IL37) Proteins
- IL-37 (IL37) (Interleukin 37 (IL37))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IL-37 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purpose
- IL-37 (aa 46-218) (human) (rec.) (His)
- Cross-Reactivity
- Human
- Characteristics
- Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag.
- Purity
- >95 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <0.1EU/μg purified protein (LAL test).
- Top Product
- Discover our top product IL37 Protein
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Interleukin 37 (IL37) (AA 1-218) protein (GST tag)
IL37 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 37 (IL37) (Active) proteinIL37 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 37 (IL37) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)IL37 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in distilled water.
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
- Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Expiry Date
- 6 months
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- Target
- IL-37 (IL37) (Interleukin 37 (IL37))
- Alternative Name
- IL-37 (IL37 Products)
- Background
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Interleukin-1 Family Member 7, IL-1F7, FIL1 zeta, IL-1X, Interleukin-1 Homolog 4, IL-1H4, Interleukin-1 zeta, IL-1 zeta, IL-1RP1, IL1F7, FIL1Z, IL1H4, IL1RP1
IL-37 (IL-1F7, IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.
- Molecular Weight
- ~20kDa (SDS-PAGE)
- UniProt
- Q9NZH6
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