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IL-33 Protein (AA 109-266)

IL33 Origin: Human, Mouse Host: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) SDS Active
Catalog No. ABIN1343980
  • Target See all IL-33 (IL33) Proteins
    IL-33 (IL33) (Interleukin 33 (IL33))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 109-266
    Origin
    • 17
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Source
    • 24
    • 8
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS)
    Specificity
    Binds to mouse and human ST2.
    Cross-Reactivity
    Human, Mouse (Murine)
    Characteristics
    Mouse IL-33 (aa 109-266) is untagged.
    Purity
    >95 % (SDS-PAGE)
    Endotoxin Level
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IL33 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Activates ST2-dependent NF-kappaB pathway.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with 100 μL sterile water.
    Concentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Target
    IL-33 (IL33) (Interleukin 33 (IL33))
    Alternative Name
    IL-33 (IL33 Products)
    Synonyms
    IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
    Background
    Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
    Molecular Weight
    ~18kDa
    UniProt
    Q2YEJ4
    Pathways
    Production of Molecular Mediator of Immune Response
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