STAT3 Protein (AA 1-769) (GST tag)
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- Target See all STAT3 Proteins
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-769
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Origin
- Human
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Source
- Wheat germ
- Purification tag / Conjugate
- This STAT3 protein is labelled with GST tag.
- Application
- Western Blotting (WB), ELISA, Affinity Purification (AP), Antibody Array (AA)
- Purpose
- STAT3 (Human) Recombinant Protein (P01)
- Sequence
- MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG AAPYLKTKFI CVTPTTCSNT IDLPMSPRTL DSLMQFGNNG EGAEPSAGGQ FESLTFDMEL TSECATSPM
- Characteristics
- Human STAT3 full-length ORF ( AAH00627, 1 a.a. - 769 a.a.) recombinant protein with GST-tag at N-terminal.
- Purification
- in vitro wheat germ expression system
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Preparation method: in vitro, wheat germ expression system
Product Quality tested by: 12.5% SDS-PAGE Stained with Coomassie Blue. - Restrictions
- For Research Use only
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- Buffer
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.
- Handling Advice
- Aliquot to avoid repeated freezing and thawing.
- Storage
- -80 °C
- Storage Comment
- Best use within three months from the date of receipt of this protein.
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KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer." in: Molecular cancer, Vol. 13, pp. 176, (2014) (PubMed).
: "Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening." in: Methods (San Diego, Calif.), Vol. 71, pp. 38-43, (2014) (PubMed).
: "
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KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer." in: Molecular cancer, Vol. 13, pp. 176, (2014) (PubMed).
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- Target
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
- Alternative Name
- STAT3 (STAT3 Products)
- Synonyms
- 1110034C02Rik Protein, AW109958 Protein, Aprf Protein, APRF Protein, HIES Protein, Xstat3 Protein, aprf Protein, hies Protein, stat3 Protein, wu:fc15d02 Protein, wu:fl59g06 Protein, z-Stat3 Protein, signal transducer and activator of transcription 3 Protein, signal transduction and activation of transcription 3 Protein, signal transducer and activator of transcription 3, gene 1 L homeolog Protein, signal transducer and activator of transcription 3 (acute-phase response factor) Protein, STAT3 Protein, stat3 Protein, Stat3 Protein, stat3.1.L Protein
- Background
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Full Gene Name: signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms: APRF,FLJ20882,HIES,MGC16063 - Gene ID
- 6774
- Pathways
- JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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