GPR177/WLS Protein (His tag)

Catalog No. ABIN1098794

Product Details

Target: GPR177/WLS (WLS) (Wntless Homolog (WLS))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GPR177/WLS protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Purity: > 90 % by SDS - PAGE

Application Details

Comment:

Synonyms: Protein wntless homolog isoform 1 precursor, C1orf139, EVI, GPR177, MRP

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea, 10% glycerol

Storage: 4 °C

Storage Comment: Avoid repeated freezing and thawing cycles.

Target Details

Target: GPR177/WLS (WLS) (Wntless Homolog (WLS))

Alternative Name: WLS (WLS Products)

Synonyms: C1orf139 Protein, EVI Protein, GPR177 Protein, MRP Protein, mig-14 Protein, 5031439A09Rik Protein, AI173978 Protein, AI987742 Protein, Gpr177 Protein, gpr117 Protein, gpr177 Protein, sb:cb610 Protein, wu:fb36d04 Protein, wu:fb44d10 Protein, wu:fb50c06 Protein, zgc:64091 Protein, CG6210 Protein, Dmel\\CG6210 Protein, Evi Protein, Evi/Wls Protein, Srt Protein, Wls Protein, Wls/Evi Protein, evi Protein, srt Protein, wls/evi Protein, wntless Wnt ligand secretion mediator Protein, wntless homolog (Drosophila) Protein, wntless Protein, WLS Protein, Wls Protein, wls Protein

Background: WLS, a Wnt trafficking regulator, is a multipass transmembrane protein that regulates the sorting and secretion of Wnt protein. It is required for organogenesis during embryogenesis and for the establishment of the anterior-posterior axis. WLS promotes various cancers such as glioma tumourigenesis. The gene encoding WLS maps to human chromosome 1 and is expressed as multiple alternatively spliced isoforms. Recombinant human WLS protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molecular Weight: 17.8 kDa (155aa)

NCBI Accession: NP_079187

Pathways: WNT Signaling