HFE Protein (His tag)
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- Target See all HFE Proteins
- HFE (Hemochromatosis (HFE))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This HFE protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product HFE Protein
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Hemochromatosis (HFE) (AA 115-205) protein (GST tag)
HFE Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Hemochromatosis (HFE) proteinHFE Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % pure SDS
Hemochromatosis (HFE) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)HFE Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Hemochromatosis (HFE) (Transcript Variant 6) protein (Myc-DYKDDDDK Tag)HFE Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Hemochromatosis (HFE) (Transcript Variant 9) protein (Myc-DYKDDDDK Tag)HFE Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Comment
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Synonyms: Hereditary hemochromatosis protein, HFE1, HH, HLA-H, MVCD7, TFQTL2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea, 10% glycerol
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- HFE (Hemochromatosis (HFE))
- Alternative Name
- HFE (HFE Products)
- Synonyms
- HFE1 Protein, HH Protein, HLA-H Protein, MVCD7 Protein, TFQTL2 Protein, MR2 Protein, hemochromatosis Protein, HFE Protein, Hfe Protein
- Background
- HFE, also known as HLA-H, belongs to the MHC class I family. This protein contains 1 Ig-like C1-type (immunoglobulin-like) domain. HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta-2 microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor (TFR) with transferrin. It binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Recombinant human HFE protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 35.7kDa (308aa)
- NCBI Accession
- NP_000401
- Pathways
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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