NCR3 Protein (AA 19-138) (His tag)

Catalog No. ABIN1097236

Product Details

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Protein Type: Recombinant

Protein Characteristics: AA 19-138

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This NCR3 protein is labelled with His tag.

Purpose: Recombinant Human NCR3/NKp30/CD337 (C-6His)

Sequence: LWVSQPPEIR TLEGSSAFLP CSFNASQGRL AIGSVTWFRD EVVPGKEVRN GTPEFRGRLA PLASSRFLHD HQAELHIRDV RGHDASIYVC RVEVLGLGVG TGNGTRLVVE KEHPQLGAGT VDHHHHHH

Characteristics:

Recombinant Human NCR3/NKp30/CD337 (C-6His)

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Alternative Name: Natural Cytotoxicity Triggering Receptor 3/NCR3 (NCR3 Products)

Synonyms: MGC133750 Protein, 1C7 Protein, CD337 Protein, LY117 Protein, MALS Protein, NKp30 Protein, Nkp30 Protein, natural cytotoxicity triggering receptor 3 Protein, NCR3 Protein, Ncr3 Protein

Background: Recombinant Human Natural Cytotoxicity Triggering Receptor 3/NCR3 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Leu19-Thr138) of Human NCR3.
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed 'Natural Cytotoxicity Receptors'. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.

Molecular Weight: 12.84 kDa

UniProt: O14931

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process