IL1A Protein
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- Target See all IL1A Proteins
- IL1A (Interleukin 1 alpha (IL1A))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human Interleukin-1α/IL-1α
- Sequence
- SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
- Characteristics
- Recombinant Human Interleukin-1alpha/IL-1alpha produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids with a molecular mass of 18 kDa.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product IL1A Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 7.5.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- IL1A (Interleukin 1 alpha (IL1A))
- Alternative Name
- IL-1-alpha (IL1A Products)
- Synonyms
- IL-1A Protein, IL1 Protein, IL1-ALPHA Protein, IL1F1 Protein, IL-6 Protein, Il-1a Protein, IL-1 alpha Protein, IL-1alpha Protein, L1A Protein, interleukin 1 alpha Protein, interleukin 6 Protein, IL1A Protein, IL6 Protein, Il1a Protein
- Background
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Interleukin-1 alpha (IL1alpha) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1alpha and IL1beta that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1alpha is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1alpha. IL1alpha possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.
Alternative Names: Interleukin-1 Alpha, IL-1 Alpha, Hematopoietin-1, IL1A, IL1F1 - Molecular Weight
- 18 kDa
- UniProt
- P01583
- Pathways
- NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
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