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CNTF Protein (AA 1-200)

CNTF Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1096416
  • Target See all CNTF Proteins
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-200
    Origin
    • 15
    • 8
    • 3
    • 2
    • 2
    • 2
    Human
    Source
    • 22
    • 3
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human Ciliary Neurotrophic Factor/CNTF
    Sequence
    AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTESYVKH QGLNKNINLD SADGMPVAST DQWSELTEAE RLQENLQAYR TFHVLLARLL EDQQVHFTPT EGDFHQAIHT LLLQVAAFAY QIEELMILLE YKIPRNEADG MPINVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM
    Characteristics
    Recombinant Human Ciliary Neurotrophic Factor/CNTF is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Met200) of Human CNTF.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product CNTF Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM Cysteine, pH 7.4.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    3 months
  • Target
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Alternative Name
    cntf (CNTF Products)
    Synonyms
    GPA Protein, CNTF Protein, HCNTF Protein, AI429687 Protein, ciliary neurotrophic factor Protein, CNTF Protein, Cntf Protein
    Background
    Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.
    Alternative Names: Ciliary Neurotrophic Factor, CNTF
    Molecular Weight
    22.93 kDa
    UniProt
    P26441
    Pathways
    JAK-STAT Signaling
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