CCL26 Protein (AA 27-94)

Catalog No. ABIN1096269

Product Details

Target: CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))

Protein Type: Recombinant

Protein Characteristics: AA 27-94

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human C-C Motif Chemokine 26/CCL26 (27-94)

Sequence: MSDISKTCCF QYSHKPLPWT WVRSYEFTSN SCSQRAVIFT TKRGKKVCTH PRKKWVQKYI SLLKTPKQL

Characteristics: Recombinant Human C-C Motif Chemokine 26/CCL26 (27-94) is produced with our E. coli expression system. The target protein is expressed with sequence (Ser27-Leu94) of Human CCL26.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))

Alternative Name: CCL26/Eotaxin-3 27-94 (CCL26 Products)

Synonyms: CCL26 Protein, IMAC Protein, MIP-4a Protein, MIP-4alpha Protein, SCYA26 Protein, TSC-1 Protein, Ccl26l Protein, C-C motif chemokine ligand 26 Protein, chemokine (C-C motif) ligand 26 Protein, CCL26 Protein, Ccl26 Protein

Background: Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family, which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, Eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
Alternative Names: C-C Motif Chemokine 26, CC Chemokine IMAC, Eotaxin-3, Macrophage Inflammatory Protein 4-Alpha, MIP-4-Alpha, Small-Inducible Cytokine A26, Thymic Stroma Chemokine-1, TSC-1, CCL26, SCYA26

Molecular Weight: 8.21 kDa

UniProt: Q9Y258

Pathways: Regulation of Actin Filament Polymerization