ACVR2B Protein (AA 19-134) (His tag)
-
- Target See all ACVR2B Proteins
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-134
-
Origin
- Human
-
Source
- Human Cells
- Purification tag / Conjugate
- This ACVR2B protein is labelled with His tag.
- Purpose
- Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-6His)
- Sequence
- SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE AGGPEVTYEP PPTAPTVDHH HHHH
- Characteristics
- Recombinant Human Activin Receptor Type IIB/ACVR2B is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ser19-Thr134) of Human ACVR2B fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product ACVR2B Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
-
It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
-
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
-
- Target
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Abstract
- ACVR2B Products
- Synonyms
- ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein
- Sub Type
- Fusionprotein
- Background
-
Activin proteins that belong to the transforming growth factor-beta (TGF-beta) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
Alternative Names: Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B - Molecular Weight
- 14.37 kDa
- UniProt
- Q13705
- Pathways
- Hormone Transport, Cancer Immune Checkpoints
-