Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008].
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Latest Publications for our Proadrenomedullin products
Kannan, Rao, Mithra, Dhanashree, Baliga, Bhat: "Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India." in: International journal of pediatrics, Vol. 2018, pp. 7908148, (2018) (PubMed).
Oncel, Dilmen, Erdeve, Ozdemir, Calisici, Yurttutan, Canpolat, Oguz, Uras: "Proadrenomedullin as a prognostic marker in neonatal sepsis." in: Pediatric research, Vol. 72, Issue 5, pp. 507-12, (2012) (PubMed).
Synonyms and alternative names related to Proadrenomedullin
adrenomedullin (ADM), adrenomedullin (adm), ADM
Protein level used designations for Proadrenomedullin