PRKG1 Products
(Protein Kinase, CGMP-Dependent, Type I (PRKG1))
Categories
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011].
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Featured PRKG1 Categories
PRKG1 Antibodies
High quality antibodies with extensive validation data.
PRKG1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PRKG1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKG1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN392536
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN562400
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (3)
Cat. No.
ABIN562402
Quantity
100 μg
Datasheet
Datasheet
Recommended PRKG1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969729
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958936
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958937
Quantity
96 tests
Datasheet
Datasheet
Recommended PRKG1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316297
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316295
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509120
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PRKG1 products
: "A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension." in: The Journal of biological chemistry, Vol. 288, Issue 23, pp. 16557-66, (2013) (PubMed).Synonyms and alternative names related to PRKG1
protein kinase, cGMP-dependent, type Ia (prkg1a), protein kinase, cGMP-dependent, type I (PRKG1), protein kinase, cGMP-dependent, type I (prkg1), protein kinase, cGMP-dependent, type 1 (Prkg1), protein kinase, cGMP-dependent, type I (Prkg1), 1, AW125416, cGK, cGk1, cGK 1, cGK1, cGKI, CGKI, cGKI-alpha, cGKI-BETA, cGKI-beta, Gm19690, PKG, Pkgi, prkg1, PRKG1B, Prkg1b, Prkg1beta, PRKGR1B, Prkgr1b, zgc:63955Protein level used designations for PRKG1
- cGMP-dependent protein kinase 1
- protein kinase, cGMP-dependent, type I
- cGMP-dependent protein kinase 1, beta isozyme
- cGMP-dependent protein kinase I alpha
- cGK I alpha
- cGMP-dependent protein kinase 1-like
- cGMP dependent protein kinase type 1
- protein kinase, cGMP-dependent, regulatory, type I, beta
- CGK 1 alpha
- cGK 1 beta
- cGK1
- cGKI-alpha
- cGMP-dependent protein kinase 1, alpha isozyme
- cGMP-dependent protein kinase I
- cGK 1
- PKG1 alpha
- cGMP-dependent protein kinase type 1 alpha
- cGMP-dependent protein kinase type I beta
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