PRKACA Products
(Protein Kinase A, alpha (PRKACA))
Categories
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured PRKACA Categories
PRKACA Antibodies
High quality antibodies with extensive validation data.
PRKACA ELISA Kits
Reliable ELISA kits for a wide range of species.
PRKACA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKACA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), IF, ICC
Validations
- (4)
Cat. No.
ABIN2855997
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7146598
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6264236
Quantity
100 μL
Datasheet
Datasheet
Recommended PRKACA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965372
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965371
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965370
Quantity
96 tests
Datasheet
Datasheet
Recommended PRKACA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1316219
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316221
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316223
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PRKACA products
: "STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs." in: Molecular biology of the cell, Vol. 26, Issue 6, pp. 1141-59, (2015) (PubMed).: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." in: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).
: "Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency." in: Brain structure & function, (2014) (PubMed).
: "Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress." in: Molecular pharmacology, Vol. 86, Issue 4, pp. 450-62, (2014) (PubMed).
: "Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. ..." in: The New England journal of medicine, Vol. 370, Issue 11, pp. 1019-28, (2014) (PubMed).
: "PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group." in: Tumour biology, Vol. 33, Issue 6, pp. 2289-98, (2012) (PubMed).
: "Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases." in: Cell death and differentiation, Vol. 17, Issue 8, pp. 1325-34, (2010) (PubMed).
: "Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection." in: Journal of virology, Vol. 84, Issue 13, pp. 6410-24, (2010) (PubMed).
: "Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 14, Issue 3, pp. 355-69, (2009) (PubMed).
: "Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 64, Issue 12, pp. 1221-31, (2009) (PubMed).
Synonyms and alternative names related to PRKACA
protein kinase cAMP-activated catalytic subunit alpha (PRKACA), protein kinase cAMP-activated catalytic subunit alpha (Prkaca), protein kinase, cAMP dependent, catalytic, alpha (Prkaca), cAMP-dependent protein kinase catalytic subunit (kin-1), protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a (prkacaa), Calpha, Cs-PKA, PKA, PKACA, Pkaca, PKCA1, PKCD, zgc:158799Protein level used designations for PRKACA
- PKA C-alpha
- cAMP-dependent protein kinase catalytic subunit alpha
- protein kinase A catalytic subunit
- cAMP-dependent protein kinase catalytic subunit C alpha
- protein kinase A
- protein kinase, cAMP-dependent, catalytic, alpha
- C-alpha subunit
- sperm cAMP-dependent protein kinase catalytic subunit
- protein kinase A alpha
- prkaca
- PKA catalytic subunit alpha
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