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Presenilin 1 Products

(Presenilin 1 (PSEN1))
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].

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Featured Presenilin 1 Categories

Presenilin 1 Antibodies

High quality antibodies with extensive validation data.

Presenilin 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Presenilin 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Presenilin 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN3023160
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), FACS, IF
Validations
  • (1)
  • (4)
Cat. No. ABIN390169
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7164264
Quantity 100 μg
Datasheet Datasheet

Recommended Presenilin 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958721
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969495
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958722
Quantity 96 tests
Datasheet Datasheet

Recommended Presenilin 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316518
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7414045
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7412977
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Presenilin 1 products

Puri, Yerrathota, Home, Idowu, Chakravarthi, Ward, Singhal, Vanden Heuvel, Fields, Sharma: "Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy." in: Disease models & mechanisms, Vol. 12, Issue 12, (2020) (PubMed).

Dursun, Gezen-Ak: "Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin." in: PLoS ONE, Vol. 12, Issue 11, pp. e0188605, (2017) (PubMed).

Chu, Peng, Long, Wang, Luo, Sharma, He: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).

Paulasir, Kaoutzanis, Welch, Vandewarker, Krapohl, Lampman, Franz, Cleary: "Nonsteroidal Anti-inflammatory Drugs: Do They Increase the Risk of Anastomotic Leaks Following Colorectal Operations?" in: Diseases of the colon and rectum, Vol. 58, Issue 9, pp. 870-7, (2015) (PubMed).

Luciano, Barraco, Muraca, Ottino, Spreghini, Sforza, Rustico, Morino, Manco: "Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood." in: Pediatrics, Vol. 135, Issue 6, pp. 1074-81, (2015) (PubMed).

Lefort, Pozueta, Shelanski: "Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 31, pp. 10674-85, (2012) (PubMed).

Scarpi, Cirelli, Matrone, Castronovo, Rosini, Occhiato, Romano, Bartali, Clemente, Bottegoni, Cavalli, De Chiara, Bonini, Calissano, Palamara, Garaci, Torcia, Guarna, Cozzolino: "Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity." in: Cell death & disease, Vol. 3, pp. e389, (2012) (PubMed).

Lombardo, Filipović, Molyneux, Periyasamy, Giamas, Hu, Trivedi, Wang, Yagüe, Michel, Coombes: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).

Nie, Li, Yan, Wang, Zhao, Guo, Yin: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).

McCombs, Gibson, Palmer: "Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics." in: Molecular bioSystems, Vol. 6, Issue 9, pp. 1640-9, (2010) (PubMed).

Synonyms and alternative names related to Presenilin 1

presenilin 1 (psen1), presenilin 1 (PSEN1), presenilin 1 (Psen1), presenilin 1 L homeolog (psen1.L), ad3, AD3, Ad3h, fad, FAD, pre1, PS-1, ps1, PS1, psen, s182, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1

Protein level used designations for Presenilin 1

  • PS-1
  • presenilin-1
  • presenilin 1 (Alzheimer disease 3)
  • presenilin-1 isoform I-463
  • presenilin-1 isoform I-467
  • presenilin 1
  • presenilin-1-like
  • PS-alpha
  • presenilin alpha
  • presenilin-alpha
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