Premelanosome Protein Products
(Premelanosome Protein (PMEL))
Categories
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011].
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Featured Premelanosome Protein Categories
Premelanosome Protein Antibodies
High quality antibodies with extensive validation data.
Premelanosome Protein ELISA Kits
Reliable ELISA kits for a wide range of species.
Premelanosome Protein Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Premelanosome Protein Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Monkey, Rat
Application
IHC, IF, WB, IHC (p)
Validations
- (17)
Cat. No.
ABIN1500300
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, StM, Coat
Validations
- (5)
Cat. No.
ABIN6940589
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IF, WB, ELISA
Validations
- (4)
Cat. No.
ABIN185660
Quantity
100 μg
Datasheet
Datasheet
Recommended Premelanosome Protein ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958713
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969484
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958714
Quantity
96 tests
Datasheet
Datasheet
Recommended Premelanosome Protein Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1320014
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN6964099
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393823
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Premelanosome Protein products
: "CXCL5 as Regulator of Neutrophil Function in Cutaneous Melanoma." in: The Journal of investigative dermatology, Vol. 139, Issue 1, pp. 186-194, (2019) (PubMed).: "Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy. ..." in: Immunity, Vol. 47, Issue 4, pp. 789-802.e9, (2017) (PubMed).
: "A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells." in: Cancer research, Vol. 76, Issue 2, pp. 251-63, (2016) (PubMed).
: "ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma." in: Investigative ophthalmology & visual science, Vol. 56, Issue 12, pp. 7007-11, (2015) (PubMed).
: "MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment." in: Nature communications, Vol. 6, pp. 8755, (2015) (PubMed).
: "Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. ..." in: Nature, Vol. 507, Issue 7490, pp. 109-13, (2014) (PubMed).
: "Artificial antigen-presenting cells expressing CD80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens." in: Immunobiology, Vol. 219, Issue 8, pp. 583-92, (2014) (PubMed).
: "Mass spectrometry and imaging analysis of nanoparticle-containing vesicles provide a mechanistic insight into cellular trafficking." in: ACS nano, Vol. 8, Issue 10, pp. 10077-88, (2014) (PubMed).
: "The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant." in: Cancer research, Vol. 74, Issue 21, pp. 5989-98, (2014) (PubMed).
: "BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 26, pp. 10658-63, (2013) (PubMed).
Synonyms and alternative names related to Premelanosome Protein
premelanosome protein (PMEL), premelanosome protein (Pmel), premelanosome protein b (pmelb), premelanosome protein a (pmela), cb397, D10H12S53E, D12S53E, D12S53Eh, fdv, gp87, gp100, ME20, ME20-M, ME20M, MMP115, P1, P100, PMEL17, Pmel17, pmel17, RPE1, sb:cb397, SI, Si, SIL, SILV, Silv, silva, silver, silverb, wu:fc11g11, wu:fj24g11, zgc:136622Protein level used designations for Premelanosome Protein
- melanocyte protein PMEL
- melanocyte protein Pmel 17
- melanocyte protein mel 17
- melanocytes lineage-specific antigen GP100
- melanoma-associated ME20 antigen
- melanosomal matrix protein17
- silver locus protein homolog
- silver, mouse, homolog of
- melanocyte protein pmel 17
- silver locus protein
- retinal pigment epithelial-specific protein
- silver homolog
- 115 kDa melanosomal matrix protein
- PMEL17 protein
- melanosome matrix protein
- melanocyte protein 17
- premelanosomal protein
- fading vision
- melanosomal matrix protein
- silver homolog a
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