Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Products

(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Categories

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Antibodies

High quality antibodies with extensive validation data.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D ELISA Kits

Reliable ELISA kits for a wide range of species.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF (cc), IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN740415
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7165942
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN563650
Quantity 100 μg
Datasheet Datasheet

Recommended Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958950
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Sandwich ELISA
Validations
Cat. No. ABIN422939
Quantity 96 tests
Datasheet Datasheet

Recommended Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315910
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315909
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN5623952
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D products

Wang, Cui, Wen, Guo, Zhang, Chen: "Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway." in: Oncology letters, Vol. 12, Issue 6, pp. 4605-4612, (2017) (PubMed).

Park, Song, Kim, Han, Seol, Jang, Choi: "p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 896-904, (2012) (PubMed).

Buss, Read, Schniederjan, Gandhi, Castellino: "HDM2 promotes WIP1-mediated medulloblastoma growth." in: Neuro-oncology, Vol. 14, Issue 4, pp. 440-58, (2012) (PubMed).

Lee, Lee, Kim, Kim, Lee, Heo, Lee, Cho, Fornace, Jeong, Cha: "p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 6, Issue 3, pp. 423-31, (2011) (PubMed).

Song, Han, Sabapathy, Lee, Yu, Choi: "Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9067-76, (2010) (PubMed).

Moon, Lin, Zhang, Nguyen, Darlington, Waldman, Lu, Donehower: "Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12935-47, (2010) (PubMed).

Zhang, Wan, Mlotshwa, Vance, Berger, Chen, Lu: "Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway." in: Cancer research, Vol. 70, Issue 18, pp. 7176-86, (2010) (PubMed).

Nguyen, Slattery, Moon, Darlington, Lu, Donehower: "The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair." in: DNA repair, Vol. 9, Issue 7, pp. 813-23, (2010) (PubMed).

Lowe, Cha, Yang, Fornace: "Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5249-57, (2010) (PubMed).

Chock, Allison, Elshamy: "BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells." in: Oncogene, Vol. 29, Issue 38, pp. 5274-85, (2010) (PubMed).

Synonyms and alternative names related to Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D

protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D), protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d), protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), protein phosphatase, Mg2+/Mn2+ dependent, 1Db (ppm1db), protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog (ppm1d.L), protein phosphatase, Mg2+/Mn2+ dependent, 1Da (ppm1da), AV338790, PP2C-DELTA, ppm1d, WIP1, Wip1, wu:fj44c08, zgc:55836, zgc:77316, zgc:103518

Protein level used designations for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D

  • protein phosphatase 1D
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • protein phosphatase 2C delta isoform
  • protein phosphatase Wip1
  • wild-type p53-induced phosphatase 1
  • PP2C-delta
  • p53-induced protein phosphatase 1
  • protein phosphatase 2C isoform delta
  • protein phosphatase magnesium-dependent 1 delta
  • protein phosphatase 1D magnesium-dependent, delta
  • protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D
You are here:
Support