PPP4C Products
(Protein Phosphatase 4, Catalytic Subunit (PPP4C))
Categories
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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Featured PPP4C Categories
PPP4C Antibodies
High quality antibodies with extensive validation data.
PPP4C Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PPP4C Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (9)
Cat. No.
ABIN3022939
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7260177
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN669261
Quantity
100 μL
Datasheet
Datasheet
Recommended PPP4C ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969743
Quantity
96 tests
Datasheet
Datasheet
Recommended PPP4C Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316083
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316081
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2131274
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PPP4C products
: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." in: eLife, Vol. 3, pp. e01695, (2014) (PubMed).: "Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells." in: Biochimica et biophysica acta, Vol. 1783, Issue 8, pp. 1490-502, (2008) (PubMed).
: "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26143-8, (2004) (PubMed).
: "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46588-94, (2004) (PubMed).
: "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49551-61, (2004) (PubMed).
Synonyms and alternative names related to PPP4C
protein phosphatase 4 catalytic subunit (ppp4c), protein phosphatase 4, catalytic subunit a (ppp4ca), protein phosphatase 4 catalytic subunit (PPP4C), protein phosphatase 4, catalytic subunit (Ppp4c), protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S), 1110002D08Rik, AU016079, gc:56413, MGC75928, pp4, PP4, pp4c, PP4C, PP4C-A, pph3, PPH3, PPP4, ppp4c, ppx, PPX, Ppx, wu:fd05e08, zgc:56413Protein level used designations for PPP4C
- protein phosphatase 4, catalytic subunit
- catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit A
- PP-X
- protein phosphatase 4 (formerly X), catalytic subunit
- protein phosphatase X, catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit
- PP4C
- pp4
- protein phosphatase X
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