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PPP1R12A Proteins

(Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].

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PPP1R12A Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2729468)

PPP1R12A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

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PPP1R12A Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2729469)

PPP1R12A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

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Popular PPP1R12A Proteins

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PPP1R12A Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2729468

Quantity 20 μg

Datasheet Datasheet

PPP1R12A Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2729469

Quantity 20 μg

Datasheet Datasheet

Aliases for PPP1R12A Proteins

protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) Proteins
protein phosphatase 1 regulatory subunit 12A (PPP1R12A) Proteins
protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) Proteins
1200015F06Rik Proteins
5730577I22Rik Proteins
AA792106 Proteins
AV099298 Proteins
D10Ertd625e Proteins
M110 Proteins
M130 Proteins
MBS Proteins
MBSP Proteins
Mypt1 Proteins
MYPT1 Proteins

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