PPP1R12A Products
(Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
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Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
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Featured PPP1R12A Categories
PPP1R12A Antibodies
High quality antibodies with extensive validation data.
PPP1R12A ELISA Kits
Reliable ELISA kits for a wide range of species.
PPP1R12A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PPP1R12A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF, FACS
Validations
- (9)
Cat. No.
ABIN6391349
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (6)
Cat. No.
ABIN6146059
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (7)
Cat. No.
ABIN3043902
Quantity
100 μg
Datasheet
Datasheet
Recommended PPP1R12A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380231
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended PPP1R12A Proteins
Latest Publications for our PPP1R12A products
: "Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica." in: Scientific reports, Vol. 6, pp. 32257, (2018) (PubMed).: "Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway." in: Biomedicine & pharmacotherapy, Vol. 88, pp. 384-394, (2017) (PubMed).
: "The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia." in: Neural regeneration research, Vol. 10, Issue 9, pp. 1441-9, (2015) (PubMed).
: "Chlamydia trachomatis inclusion membrane protein CT228 recruits elements of the myosin phosphatase pathway to regulate release mechanisms." in: Cell reports, Vol. 3, Issue 6, pp. 1921-31, (2013) (PubMed).
: "Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37250-7, (2001) (PubMed).
: "Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)" in: Science (New York, N.Y.), Vol. 273, Issue 5272, pp. 245-8, (1996) (PubMed).
: "Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M." in: FEBS letters, Vol. 356, Issue 1, pp. 51-5, (1995) (PubMed).
Synonyms and alternative names related to PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a), protein phosphatase 1 regulatory subunit 12A (PPP1R12A), protein phosphatase 1, regulatory subunit 12A (Ppp1r12a), 1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, M110, M130, MBS, MBSP, Mypt1, MYPT1Protein level used designations for PPP1R12A
- myosin phosphatase target subunit 1
- myosin phosphatase, target subunit 1
- myosin phosphatase-targeting subunit 1
- protein phosphatase 1 regulatory subunit 12A
- myosin binding subunit
- protein phosphatase 1, regulatory (inhibitor) subunit 12A
- protein phosphatase myosin-binding subunit
- PP-1M
- protein phosphatase subunit 1M
- serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110
- smooth muscle myosin phosphatase myosin-binding subunit
- 130 kDa myosin-binding subunit of smooth muscle myosin phophatase
- 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase
- 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133)
- PP1M subunit M110
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