POMC Products
(Proopiomelanocortin (POMC))
Categories
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
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Featured POMC Categories
POMC Antibodies
High quality antibodies with extensive validation data.
POMC ELISA Kits
Reliable ELISA kits for a wide range of species.
POMC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POMC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN185387
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (5)
Cat. No.
ABIN519039
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, ICC
Validations
- (4)
Cat. No.
ABIN5542293
Quantity
100 μL
Datasheet
Datasheet
Recommended POMC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958845
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969634
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969633
Quantity
96 tests
Datasheet
Datasheet
Recommended POMC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1315730
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124600
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667920
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our POMC products
: "A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 31, Issue 1-2, pp. 17-29, (2020) (PubMed).: "Hindbrain dorsal vagal complex AMPK controls hypothalamic gluco-regulatory transmitter and counter-regulatory hormone responses to hypoglycemia." in: Brain research bulletin, Vol. 144, pp. 171-179, (2019) (PubMed).
: "Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice." in: The Journal of biological chemistry, Vol. 294, Issue 13, pp. 4946-4955, (2019) (PubMed).
: "Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide." in: Neuroscience, Vol. 383, pp. 46-59, (2019) (PubMed).
: "Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity." in: The Journal of clinical investigation, Vol. 128, Issue 3, pp. 1125-1140, (2018) (PubMed).
: "Air-liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2." in: Cell death discovery, Vol. 3, pp. 17001, (2017) (PubMed).
: "A potential role for the secretogranin II-derived peptide EM66 in the hypothalamic regulation of feeding behaviour." in: Journal of neuroendocrinology, Vol. 29, Issue 3, (2017) (PubMed).
: "Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation." in: Neurochemical research, Vol. 41, Issue 9, pp. 2289-99, (2016) (PubMed).
: "Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying." in: BioMed research international, Vol. 2015, pp. 651048, (2016) (PubMed).
: "Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury." in: Neural regeneration research, Vol. 7, Issue 22, pp. 1729-35, (2015) (PubMed).
Synonyms and alternative names related to POMC
proopiomelanocortin a (pomca), pro-opiomelanocortin-alpha (Pomc), proopiomelanocortin (POMC), proopiomelanocortin (Pomc), ACTH, alpha-MSH, alphaMSH, BE, Beta-LPH, beta-MSH, Clip, CLIP, Gamma-LPH, gamma-MSH, LPH, MSH, Npp, NPP, POC, pomc, Pomc-1, Pomc1, Pomc2, SI:bZ36D5.1, si:bz36d5.2, SI:bZ36D5.4Protein level used designations for POMC
- beta-endorphin
- pro-opiomelanocortin
- adrenal corticotropic hormone
- adrenocorticotropic hormone
- alpha-melanocyte stimulating hormone
- corticotropin-like intermediary peptide
- corticotropin-lipotropin
- melanotropin gamma
- met-enkephalin
- adrenocorticotropin
- alpha-MSH
- alpha-melanocyte-stimulating hormone
- beta-LPH
- beta-MSH
- beta-melanocyte-stimulating hormone
- gamma-LPH
- gamma-MSH
- lipotropin beta
- lipotropin gamma
- melanotropin alpha
- melanotropin beta
- opiomelanocortin prepropeptide
- pro-ACTH-endorphin
- proopiomelanocortin preproprotein
- pro-opiomelanocortin-alpha
- proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
- proopiomelanocortin, beta (endorphin, beta)
- proopoimelanocortin, beta (endorphin, beta)
- Corticotropin-lipotropin
- beta-lipotropin
- beta-melanocyte stimulating hormone
- pro-opiomelanocortin a-1
- pro-opiomelanocortin a-2
- pro-opiomelanocortin b-1
- pro-opiomelanocortin b-2
Did you look for something else?
- POM121L2
- POM121L12
- POM121C
- POM121B
- POM121
- Polyubiquitin 3
- Polypyrimidine Tract-Binding Protein
- Polymyxin B
- Polychaetoid
- Polybromo 1
- Poly(A) Binding Protein, Nuclear 1-Like (Cytoplasmic)
- Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2
- Poly(A) Binding Protein, Cytoplasmic 1-Like
- Poly(A) Binding Protein, Cytoplasmic 1
- Poly-U Binding Splicing Factor 60KDa
- Poly-ADP-Ribose
- Poly Ubiquitin
- Poly Serum Antigen
- Poly A Binding Protein Nuclear 1
- POLRMT
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