POLG Products
(Polymerase (DNA Directed), gamma (POLG))
Categories
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured POLG Categories
POLG Antibodies
High quality antibodies with extensive validation data.
POLG ELISA Kits
Reliable ELISA kits for a wide range of species.
POLG Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POLG Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, ICC, IP
Validations
- (5)
Cat. No.
ABIN2854742
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN1714946
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (2)
Cat. No.
ABIN7441298
Quantity
100 μL
Datasheet
Datasheet
Recommended POLG ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958688
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5657981
Quantity
96 tests
Datasheet
Datasheet
Recommended POLG Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315642
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7408237
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092149
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our POLG products
: "The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways." in: Redox biology, Vol. 12, pp. 987-1003, (2017) (PubMed).: "DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria." in: DNA repair, Vol. 60, pp. 77-88, (2017) (PubMed).
: "Valproic acid-induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model." in: Hepatology (Baltimore, Md.), Vol. 61, Issue 5, pp. 1730-9, (2015) (PubMed).
: "Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ..." in: BMC medical genomics, Vol. 6, pp. 22, (2013) (PubMed).
: "Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and progressive external ophthalmoplegia [corrected]." in: Human molecular genetics, Vol. 22, Issue 12, pp. 2411-22, (2013) (PubMed).
: "Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine." in: Mutation research, Vol. 664, Issue 1-2, pp. 28-38, (2009) (PubMed).
Synonyms and alternative names related to POLG
polymerase (DNA) gamma, catalytic subunit L homeolog (polg.L), DNA polymerase gamma, catalytic subunit (Polg), DNA polymerase gamma, catalytic subunit (POLG), polymerase (DNA directed), gamma (POLG), polymerase (DNA directed), gamma (polg), polymerase (DNA directed), gamma (Polg), AA409516, MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG, POLG1, POLGA, PolgA, SANDO, SCAEProtein level used designations for POLG
- DNA polymerase gamma
- DNA polymerase subunit gamma-1
- DNA-directed DNA polymerase gamma
- mitochondrial DNA polymerase catalytic subunit
- polG-alpha
- polymerase (DNA directed), gamma
- DNA polymerase subunit gamma-1-like
- PolG-alpha
- DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)
- Pol gamma
- mitochondrial DNA polymerase gamma
- mitochondrial DNA polymerase-gamma
- mitochondrial polymerase gamma
- polymerase, gamma
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