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POLD3 Products

(Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3))

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This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].

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Featured POLD3 Categories

POLD3 Antibodies

High quality antibodies with extensive validation data.

POLD3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended POLD3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (4)
Cat. No. ABIN6145881
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7075130
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7263229
Quantity 200 μL
Datasheet Datasheet

Recommended POLD3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6216202
Quantity 96 tests
Datasheet Datasheet

Recommended POLD3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315628
Quantity 10 μg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1459509
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our POLD3 products

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Bursomanno, Beli, Khan, Minocherhomji, Wagner, Bekker-Jensen, Mailand, Choudhary, Hickson, Liu: "Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells." in: DNA repair, Vol. 25, pp. 84-96, (2014) (PubMed).

Vashistha, Singhal, Malhotra, Husain, Mathieson, Saleem, Kuriakose, Seshan, Wilk, Delvalle, Peruzzi, Giorgio, Pelicci, Smithies, Kim, Kakoki, Reiss, Meggs: "Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney." in: American journal of physiology. Renal physiology, Vol. 303, Issue 12, pp. F1629-40, (2012) (PubMed).

Johnson, ODonnell: "Cellular DNA replicases: components and dynamics at the replication fork." in: Annual review of biochemistry, Vol. 74, pp. 283-315, (2005) (PubMed).

Shikata, Ohta, Yamada, Obuse, Yoshikawa, Tsurimoto: "The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta." in: Journal of biochemistry, Vol. 129, Issue 5, pp. 699-708, (2001) (PubMed).

Hindges, Hübscher: "DNA polymerase delta, an essential enzyme for DNA transactions." in: Biological chemistry, Vol. 378, Issue 5, pp. 345-62, (1997) (PubMed).

Synonyms and alternative names related to POLD3

polymerase (DNA-directed), delta 3, accessory subunit L homeolog (pold3.L), polymerase (DNA-directed), delta 3, accessory subunit (pold3), DNA polymerase delta 3, accessory subunit (POLD3), polymerase (DNA-directed), delta 3, accessory subunit (Pold3), DNA polymerase delta 3, accessory subunit (Pold3), 2410142G14Rik, C85233, P66, P68, zgc:136471

Protein level used designations for POLD3

  • DNA-directed DNA polymerase delta 3
  • DNA polymerase delta p66 subunit
  • DNA polymerase delta subunit 3
  • polymerase (DNA-directed), delta 3, accessory subunit
  • DNA polymerase delta subunit 3-like
  • DNA polymerase delta subunit p66
  • Pol delta C subunit (p66)
  • GC12
  • polymerase (DNA directed), delta 3
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