POLB Products
(Polymerase (DNA Directed), beta (POLB))
Categories
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011].
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Featured POLB Categories
POLB Antibodies
High quality antibodies with extensive validation data.
POLB ELISA Kits
Reliable ELISA kits for a wide range of species.
POLB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POLB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (6)
Cat. No.
ABIN3022385
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (4)
Cat. No.
ABIN6264332
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN1327635
Quantity
50 μL
Datasheet
Datasheet
Recommended POLB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958686
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381085
Quantity
96 tests
Datasheet
Datasheet
Recommended POLB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124515
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124514
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315620
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our POLB products
: "DNA polymerase beta participates in mitochondrial DNA repair." in: Molecular and cellular biology, (2017) (PubMed).: "p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146031, (2016) (PubMed).
: "Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade." in: Biochemical pharmacology, Vol. 105, pp. 23-33, (2016) (PubMed).
: "ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli." in: DNA repair, Vol. 45, pp. 44-55, (2016) (PubMed).
: "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner." in: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 2, pp. 269-76, (2015) (PubMed).
: "Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 28, pp. 8602-7, (2015) (PubMed).
: "miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium." in: Toxicology letters, Vol. 229, Issue 1, pp. 319-26, (2014) (PubMed).
: "Age-dependent decline of DNA base excision repair activity in rat cortical neurons." in: Mechanisms of ageing and development, Vol. 133, Issue 4, pp. 186-94, (2012) (PubMed).
: "The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death." in: Nature cell biology, Vol. 12, Issue 6, pp. 563-71, (2010) (PubMed).
: "DNA polymerase beta-dependent long patch base excision repair in living cells." in: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).
Synonyms and alternative names related to POLB
polymerase (DNA directed), beta (polb), DNA polymerase beta (POLB), DNA polymerase X family protein (polB), polymerase (DNA directed), beta S homeolog (polb.S), polymerase (DNA directed), beta (Polb), DNA polymerase beta (Polb), A430088C08Rik, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, POLB, wu:fa97a05, zgc:109924Protein level used designations for POLB
- DNA-directed DNA polymerase beta
- DNA polymerase beta
- polymerase (DNA directed), beta
- DNA polymerase beta-like
- DNA pol beta
- DNA polymerase beta subunit
- mutant DNA polymerase beta
- Pol beta
- polymerase-beta
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