PNKP Products
(Polynucleotide Kinase 3'-Phosphatase (PNKP))
Categories
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010].
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Featured PNKP Categories
PNKP Antibodies
High quality antibodies with extensive validation data.
PNKP ELISA Kits
Reliable ELISA kits for a wide range of species.
PNKP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PNKP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (8)
Cat. No.
ABIN6145836
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN7262583
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
Cat. No.
ABIN564910
Quantity
50 μL
Datasheet
Datasheet
Recommended PNKP ELISA Kits
Recommended PNKP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315552
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315550
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3086075
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PNKP products
: "MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas." in: Cancer discovery, Vol. 9, Issue 4, pp. 526-545, (2019) (PubMed).: "Mechanism for recycling tRNAs on stalled ribosomes." in: Nature structural & molecular biology, Vol. 26, Issue 5, pp. 343-349, (2019) (PubMed).
: "Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription." in: eLife, Vol. 8, (2019) (PubMed).
: "In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. ..." in: Nature communications, Vol. 9, Issue 1, pp. 3501, (2018) (PubMed).
: "Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response." in: Journal of proteome research, Vol. 14, Issue 12, pp. 5157-68, (2016) (PubMed).
: "Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability." in: Nucleic acids research, Vol. 43, Issue 7, pp. 3667-79, (2015) (PubMed).
: "Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability." in: The EMBO journal, Vol. 34, Issue 19, pp. 2465-80, (2015) (PubMed).
: "Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage." in: Nucleic acids research, Vol. 39, Issue 21, pp. 9224-37, (2011) (PubMed).
: "Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex." in: Biochemistry, Vol. 42, Issue 41, pp. 12077-84, (2003) (PubMed).
: "Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining." in: The EMBO journal, Vol. 21, Issue 11, pp. 2827-32, (2002) (PubMed).
Synonyms and alternative names related to PNKP
polynucleotide kinase 3'-phosphatase (PNKP), polynucleotide kinase 3'-phosphatase (Pnkp), polynucleotide kinase 3'-phosphatase (Tc00.1047053507017.50), polynucleotide kinase 3'-phosphatase (Tc00.1047053505807.190), polynucleotide kinase 3'-phosphatase (Tb927.6.1580), polynucleotide kinase 3'-phosphatase (BBOV_IV000690), polynucleotide kinase 3'-phosphatase (CC1G_05202), hypothetical protein (PGTG_20262), hypothetical protein (PGTG_18987), polynucleotide kinase 3'-phosphatase (pnkp.S), polynucleotide kinase 3'-phosphatase (pnkp), polynucleotide kinase 3'- phosphatase (Pnkp), 21.m03011, 1810009G08Rik, EIEE10, MCSZ, PNK, Tb06.28P18.320Protein level used designations for PNKP
- DNA 5'-kinase/3'-phosphatase
- Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)
- bifunctional polynucleotide phosphatase/kinase
- polynucleotide kinase 3'-phosphatase
- polynucleotide kinase-3'-phosphatase
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