PMEPA1 Products
(Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))
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This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
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Featured PMEPA1 Categories
PMEPA1 Antibodies
High quality antibodies with extensive validation data.
PMEPA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PMEPA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PMEPA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, StM
Validations
- (5)
Cat. No.
ABIN6940417
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC, StM
Validations
- (3)
Cat. No.
ABIN6940418
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (8)
- (2)
Cat. No.
ABIN566055
Quantity
100 μg
Datasheet
Datasheet
Recommended PMEPA1 ELISA Kits
Recommended PMEPA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315510
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3117192
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3129250
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PMEPA1 products
: "Mutation or loss of p53 differentially modifies TGF? action in ovarian cancer." in: PLoS ONE, Vol. 9, Issue 2, pp. e89553, (2014) (PubMed).: "TGF-? induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer." in: Genes & cancer, Vol. 5, Issue 9-10, pp. 320-36, (2014) (PubMed).
: "Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma." in: Cancer research, Vol. 73, Issue 13, pp. 3888-901, (2013) (PubMed).
: "TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways." in: Carcinogenesis, Vol. 34, Issue 8, pp. 1764-72, (2013) (PubMed).
: "High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone." in: Cellular & molecular biology letters, Vol. 12, Issue 3, pp. 370-7, (2012) (PubMed).
: "TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling." in: Molecular cell, Vol. 37, Issue 1, pp. 123-34, (2010) (PubMed).
: "Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer." in: Cancer research, Vol. 70, Issue 15, pp. 6377-83, (2010) (PubMed).
: "A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 43, pp. 28988-95, (2008) (PubMed).
Synonyms and alternative names related to PMEPA1
prostate transmembrane protein, androgen induced 1 (Pmepa1), prostate transmembrane protein, androgen induced 1 (PMEPA1), prostate transmembrane protein, androgen induced 1 (pmepa1), prostate transmembrane protein, androgen induced 1 L homeolog (pmepa1.L), 2210418I02Rik, AW455466, Erg1.2, N4wbp4, PMEPA1, STAG1, Stag1, Tmepai, TMEPAI, tmepai, zgc:92731Protein level used designations for PMEPA1
- transmembrane prostate androgen-induced protein
- transmembrane, prostate androgen induced RNA
- prostate transmembrane protein, androgen induced 1
- solid tumor-associated 1 protein
- NEDD4 WW domain-binding protein 4
- Nedd4 WW binding protein 4
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