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PLAT Proteins

(Plasminogen Activator, Tissue (PLAT))
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
PLAT Protein (AA 1-562) (GST tag) PLAT Protein (AA 1-562) (GST tag) PLAT Protein (AA 1-562) (GST tag) (ABIN2566071)

PLAT Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

PLAT Protein (AA 36-310) (His tag) PLAT Protein (AA 36-310) (His tag) PLAT Protein (AA 36-310) (His tag) (ABIN6388054)

PLAT Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS

PLAT Protein (AA 311-562) (His tag) PLAT Protein (AA 311-562) (His tag) PLAT Protein (AA 311-562) (His tag) (ABIN6387935)

PLAT Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS

PLAT Proteins by Origin

Find PLAT Proteins for a variety of species such as anti-Human PLAT, anti-Mouse PLAT, anti-Rat PLAT. The species listed below are among those available. Click on a link to go to the corresponding products.

PLAT Proteins by Source

Here you will find PLAT Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PLAT Proteins by Protein Type

Here you can find PLAT Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PLAT Proteins by Application

Find PLAT Proteins validated for a specific application such as SDS, WB, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PLAT Proteins by Biological Activity

Find PLAT Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular PLAT Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN2566071
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN6388054
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN6387935
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source
Validations
Cat. No. ABIN1111994
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7504551
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7504553
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7504552
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7404083
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390724
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7505738
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7197374
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7197370
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390733
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390727
Quantity 100 μg
Datasheet Datasheet
Reactivity Pig
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390730
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PLAT Proteins

Wang, Luo, Masci, Crawford, Xiao: "Influence of Interleukin-1 Beta on Platelet-Poor Plasma Clot Formation: A Potential Impact on Early Bone Healing." in: PloS one, Vol. 11, Issue 2, pp. e0149775, (2016) (PubMed).

Bongoni, Kiermeir, Schnider, Jenni, Garimella, Bähr, Klymiuk, Wolf, Ayares, Voegelin, Constantinescu, Seebach, Rieben: "Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions." in: Transplantation, (2015) (PubMed).

Harr, Moore, Chin, Chapman, Ghasabyan, Stringham, Banerjee, Silliman: "Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early." in: European journal of trauma and emergency surgery : official publication of the European Trauma Society, Vol. 41, Issue 1, pp. 49-56, (2015) (PubMed).

Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: "Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions." in: International journal for parasitology, Vol. 45, Issue 9-10, pp. 613-27, (2015) (PubMed).

Mantuano, Lam, Shibayama, Campana, Gonias: "The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration." in: Journal of cell science, (2015) (PubMed).

Lin, Jin, Hu: "Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway." in: The Journal of biological chemistry, Vol. 290, Issue 12, pp. 7910-7, (2015) (PubMed).

Shahrour, Keck, Jankun: "Application of long-acting VLHL PAI-1 during sutureless partial nephrectomy in mice reduces bleeding." in: BioMed research international, Vol. 2015, pp. 392862, (2015) (PubMed).

Kindell, Keck, Jankun: "Comparison between the clot-protecting activity of a mutant plasminogen activator inhibitor-1 with a very long half-life and 6-aminocaproic acid." in: Experimental and therapeutic medicine, Vol. 9, Issue 6, pp. 2339-2343, (2015) (PubMed).

Chen, Chu, Brumberg: "Experience-dependent regulation of tissue-type plasminogen activator in the mouse barrel cortex." in: Neuroscience letters, Vol. 599, pp. 152-7, (2015) (PubMed).

Wu, Torre, Cuellar-Giraldo, Cheng, Yi, Bichler, García, Yepes: "Tissue-type plasminogen activator triggers the synaptic vesicle cycle in cerebral cortical neurons." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, (2015) (PubMed).

Aliases for PLAT Proteins

plasminogen activator, tissue type (PLAT) Proteins
plasminogen activator, tissue (Plat) Proteins
plasminogen activator, tissue type (Plat) Proteins
plasminogen activator, tissue (PLAT) Proteins
plasminogen activator, tissue (plat) Proteins
plasminogen activator, tissue type (plat) Proteins
chromosome 20 open reading frame 181 (C20orf181) Proteins
plasminogen activator, tissue L homeolog (plat.L) Proteins
AU020998 Proteins
AW212668 Proteins
D8Ertd2e Proteins
PATISS Proteins
Plat Proteins
plat Proteins
T-PA Proteins
t-pa Proteins
TPA Proteins
tPA Proteins
tpa Proteins
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