PLAT Products
(Plasminogen Activator, Tissue (PLAT))
Categories
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured PLAT Categories
PLAT Antibodies
High quality antibodies with extensive validation data.
PLAT ELISA Kits
Reliable ELISA kits for a wide range of species.
PLAT Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PLAT Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (6)
Cat. No.
ABIN2855635
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN1860843
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7431908
Quantity
100 μL
Datasheet
Datasheet
Recommended PLAT ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (5)
Cat. No.
ABIN6730952
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958608
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969358
Quantity
96 tests
Datasheet
Datasheet
Recommended PLAT Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN2566071
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN6388054
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN6387935
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PLAT products
: "Intravenous Glu-plasminogen attenuates cholesterol crystal embolism-induced thrombotic angiopathy, acute kidney injury and kidney infarction." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, (2022) (PubMed).: "Urokinase receptor and tissue plasminogen activator as immediate-early genes in pentylenetetrazole-induced seizures in the mouse brain." in: The European journal of neuroscience, Vol. 51, Issue 7, pp. 1559-1572, (2020) (PubMed).
: "Sodium aescinate significantly suppress postoperative peritoneal adhesion by inhibiting the RhoA/ROCK signaling pathway." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 69, pp. 153193, (2020) (PubMed).
: "Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Nanoparticles for Thrombolysis without Vascular Damage: A Synergistic Nonpharmaceutical Strategy." in: ACS nano, Vol. 13, Issue 3, pp. 3387-3403, (2019) (PubMed).
: "Mechanical Adaptability of the MMP-Responsive Film Improves the Functionality of Endothelial Cell Monolayer." in: Advanced healthcare materials, Vol. 6, Issue 14, (2018) (PubMed).
: "Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits." in: Biochimica et biophysica acta, Vol. 1863, Issue 4, pp. 991-1001, (2017) (PubMed).
: "Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema." in: The Journal of allergy and clinical immunology, Vol. 140, Issue 1, pp. 170-176, (2017) (PubMed).
: "Alteration of Hemostatic Parameters in Patients with Different Levels of Subclinical Hypothyroidism and the Effect of L-thyroxine Treatment." in: Annals of clinical and laboratory science, Vol. 47, Issue 1, pp. 29-35, (2017) (PubMed).
: "Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 41, Issue 6, pp. 2133-2149, (2017) (PubMed).
: "Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems." in: Science immunology, Vol. 2, Issue 15, (2017) (PubMed).
Synonyms and alternative names related to PLAT
plasminogen activator, tissue type (PLAT), plasminogen activator, tissue (Plat), plasminogen activator, tissue type (Plat), plasminogen activator, tissue (PLAT), plasminogen activator, tissue (plat), plasminogen activator, tissue type (plat), chromosome 20 open reading frame 181 (C20orf181), plasminogen activator, tissue L homeolog (plat.L), AU020998, AW212668, D8Ertd2e, PATISS, Plat, plat, T-PA, t-pa, TPA, tPA, tpaProtein level used designations for PLAT
- alteplase
- plasminogen activator, tissue type
- reteplase
- t-plasminogen activator
- tissue plasminogen activator (t-PA)
- tissue-type plasminogen activator
- t-PA
- tissue plasminogen activator
- tPA
- T-plasminogen activator
- plasminogen activator, tissue
- tissue-type plasminogen activator-like
Did you look for something else?
- Plastin 3
- Plasmolipin
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- Plasmodium Falciparum Histidine Rich Protein 2
- Plasmodium Falciparum
- Plasminogen Activator
- Plasmin/antiplasmin Complex
- Plasmin
- Plasmepsin-1
- PLAP
- Plakophilin 4
- Plakophilin 3
- Plakophilin 2
- Plakophilin 1
- PLAGL2
- PLAGL1
- PLAG1
- Placental Protein
- PLAC9
- PLAC8-Like 1
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