PKC iota Products
(Protein Kinase C, iota (PRKCI))
Categories
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008].
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Featured PKC iota Categories
PKC iota Antibodies
High quality antibodies with extensive validation data.
PKC iota ELISA Kits
Reliable ELISA kits for a wide range of species.
PKC iota Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PKC iota Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7444109
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (5)
Cat. No.
ABIN562391
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (3)
Cat. No.
ABIN391010
Quantity
400 μL
Datasheet
Datasheet
Recommended PKC iota ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1116783
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1116784
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1057780
Quantity
96 tests
Datasheet
Datasheet
Recommended PKC iota Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
Cat. No.
ABIN1316270
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316272
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509106
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PKC iota products
: "PKCiota promotes ovarian tumor progression through deregulation of cyclin E." in: Oncogene, Vol. 35, Issue 19, pp. 2428-40, (2016) (PubMed).: "PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling." in: Biochemical and biophysical research communications, Vol. 470, Issue 2, pp. 306-12, (2016) (PubMed).
: "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 308, Issue 9, pp. G745-56, (2015) (PubMed).
: "Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells." in: Biology open, Vol. 2, Issue 11, pp. 1264-9, (2013) (PubMed).
: "Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma." in: The Journal of surgical research, Vol. 154, Issue 1, pp. 143-9, (2009) (PubMed).
: "Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 1, pp. 70-5, (2008) (PubMed).
: "Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 644-54, (2008) (PubMed).
: "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota." in: Cancer research, Vol. 68, Issue 18, pp. 7403-8, (2008) (PubMed).
: "Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms." in: The Journal of biological chemistry, Vol. 281, Issue 44, pp. 33773-88, (2006) (PubMed).
: "Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22118-23, (2004) (PubMed).
Synonyms and alternative names related to PKC iota
protein kinase C iota (PRKCI), protein kinase C, iota (prkci), protein kinase C, iota (Prkci), protein kinase C iota (Prkci), 2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkci, Pkcl, PKClambda, PRKCI, PrkclProtein level used designations for PKC iota
- PRKC-lambda/iota
- aPKC-lambda/iota
- atypical protein kinase C-lambda/iota
- protein kinase C iota type
- heart and soul protein
- nPKC-iota
- protein kinase C, iota
- protein kinase C iota
- protein kinase C, lambda
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