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PKC gamma Products

(Protein Kinase C, gamma (PRKCG))
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008].

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Featured PKC gamma Categories

PKC gamma Antibodies

High quality antibodies with extensive validation data.

PKC gamma ELISA Kits

Reliable ELISA kits for a wide range of species.

PKC gamma Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PKC gamma Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN703285
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN6257417
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN391009
Quantity 400 μL
Datasheet Datasheet

Recommended PKC gamma ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962223
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969722
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958929
Quantity 96 tests
Datasheet Datasheet

Recommended PKC gamma Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316265
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509105
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390385
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PKC gamma products

Gan, Wang, Zhao, Wu, Yang, Peng: "5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors." in: Drug design, development and therapy, Vol. 10, pp. 711-21, (2016) (PubMed).

Shimobayashi, Wagner, Kapfhammer: "Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKC? Activity and Regulates Purkinje Cell Dendritic Growth." in: Molecular neurobiology, (2015) (PubMed).

Zhang, Xu, Song, Yao, Ji: "Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity." in: Journal of translational medicine, Vol. 12, pp. 236, (2015) (PubMed).

Ji, Hassler, Shimobayashi, Paka, Streit, Kapfhammer: "Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14." in: Neurobiology of disease, Vol. 70, pp. 1-11, (2014) (PubMed).

Verbeek, Knight, Harmison, Fischbeck, Howell: "Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting." in: Brain : a journal of neurology, Vol. 128, Issue Pt 2, pp. 436-42, (2005) (PubMed).

Uchino, Sakai, Kashiwagi, Shirai, Shinohara, Hirose, Iino, Yamamura, Saito: "Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 2254-61, (2004) (PubMed).

Kawakami, Kitaura, Yao, McHenry, Kawakami, Newton, Kang, Kato, Leitges, Rawlings, Kawakami: "A Ras activation pathway dependent on Syk phosphorylation of protein kinase C." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 16, pp. 9470-5, (2003) (PubMed).

Yabe, Sasaki, Chen, Raskind, Bird, Yamashita, Tsuji, Kikuchi, Tashiro: "Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma." in: Archives of neurology, Vol. 60, Issue 12, pp. 1749-51, (2003) (PubMed).

van de Warrenburg, Verbeek, Piersma, Hennekam, Pearson, Knoers, Kremer, Sinke: "Identification of a novel SCA14 mutation in a Dutch autosomal dominant cerebellar ataxia family." in: Neurology, Vol. 61, Issue 12, pp. 1760-5, (2003) (PubMed).

Saito, Shirai: "Protein kinase C gamma (PKC gamma): function of neuron specific isotype." in: Journal of biochemistry, Vol. 132, Issue 5, pp. 683-7, (2002) (PubMed).

Synonyms and alternative names related to PKC gamma

protein kinase C gamma (PRKCG), protein kinase C, gamma (Prkcg), protein kinase C gamma type (LOC484316), protein kinase C gamma (Prkcg), PKC, PKC-gamma, PKCC, Pkcc, PKCG, PKCgamma, PKCI, Prkc, Prkcc, PRKCG, RATPKCI, SCA14

Protein level used designations for PKC gamma

  • protein kinase C, gamma
  • protein kinase C gamma type-like
  • protein kinase C gamma type
  • PKC-gamma
  • protein kinase C type I (gamma type)
  • PKC-delta
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