PITX2 Products
(Paired-Like Homeodomain 2 (PITX2))
Categories
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured PITX2 Categories
PITX2 Antibodies
High quality antibodies with extensive validation data.
PITX2 ELISA Kits
Reliable ELISA kits for a wide range of species.
PITX2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PITX2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7163465
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
- (3)
Cat. No.
ABIN562251
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC
Validations
- (1)
- (4)
Cat. No.
ABIN2776373
Quantity
100 μL
Datasheet
Datasheet
Recommended PITX2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Chicken
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231839
Quantity
96 tests
Datasheet
Datasheet
Recommended PITX2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315189
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315185
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315187
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PITX2 products
: "Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/?-catenin signaling." in: Stem cells and development, Vol. 22, Issue 5, pp. 828-39, (2013) (PubMed).: "PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3." in: Investigative ophthalmology & visual science, Vol. 52, Issue 10, pp. 7625-33, (2011) (PubMed).
: "Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells." in: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 34829-38, (2009) (PubMed).
: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
: "Absence of PITX2, BARX1, and FOXC1 mutations in De Hauwere syndrome (Axenfeld-Rieger anomaly, hydrocephaly, hearing loss): a 25-year follow up." in: American journal of medical genetics. Part A, Vol. 143A, Issue 11, pp. 1227-30, (2007) (PubMed).
: "Cytogenetically invisible microdeletions involving PITX2 in Rieger syndrome." in: Clinical genetics, Vol. 72, Issue 5, pp. 464-70, (2007) (PubMed).
: "Variants conferring risk of atrial fibrillation on chromosome 4q25. ..." in: Nature, Vol. 448, Issue 7151, pp. 353-7, (2007) (PubMed).
Synonyms and alternative names related to PITX2
paired like homeodomain 2 (PITX2), paired-like homeodomain transcription factor 2 (Pitx2), paired-like homeodomain 2 (pitx2), paired-like homeodomain 2 (Pitx2), paired like homeodomain 2 S homeolog (pitx2.S), paired like homeodomain 2 (pitx2), paired like homeodomain 2 L homeolog (pitx2.L), paired like homeodomain 2 (Pitx2), 9430085M16Rik, ARP1, arp1, Brx1, brx1, Brx1a, Brx1b, IDG2, idg2, IGDS, igds, IGDS2, igds2, IHG2, ihg2, IRID2, irid2, Munc30, Otlx2, otlx2, pitx-2, pitx2, pitx2-A, Pitx2a, pitx2a, Pitx2b, Pitx2c, pitx2c, Pitx2cbeta, PTX2, Ptx2, ptx2, RGS, rgs, RIEG, Rieg, rieg, RIEG1, rieg1, RS, xpitx2, xPtx2, XPtx2b, zgc:110508Protein level used designations for PITX2
- ALL1-responsive protein ARP1
- all1-responsive gene 1
- homeobox protein PITX2
- paired-like homeodomain transcription factor 2
- pituitary homeobox 2
- rieg bicoid-related homeobox transcription factor 1
- solurshin
- BRX1 homeoprotein
- orthodenticle-like homeobox 2
- paired-like homeodomain transcription factor Munc 30
- paired-like homeodomain transcription factor 2a
- pitx2b
- homeodomain transcription factor 2
- rPtx2
- cPITX2
- transcription factor Pitx2
- homeodomain transcription factor Pitx2
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