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PITX2 Products

(Paired-Like Homeodomain 2 (PITX2))

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This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

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Featured PITX2 Categories

PITX2 Antibodies

High quality antibodies with extensive validation data.

PITX2 ELISA Kits

Reliable ELISA kits for a wide range of species.

PITX2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PITX2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7163465
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (2)
  • (3)
Cat. No. ABIN562251
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC
Validations
  • (1)
  • (4)
Cat. No. ABIN2776373
Quantity 100 μL
Datasheet Datasheet

Recommended PITX2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Chicken
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6231839
Quantity 96 tests
Datasheet Datasheet

Recommended PITX2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315189
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315185
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315187
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PITX2 products

Hatou, Yoshida, Higa, Miyashita, Inagaki, Okano, Tsubota, Shimmura: "Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/?-catenin signaling." in: Stem cells and development, Vol. 22, Issue 5, pp. 828-39, (2013) (PubMed).

Strungaru, Footz, Liu, Berry, Belleau, Semina, Raymond, Walter: "PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3." in: Investigative ophthalmology & visual science, Vol. 52, Issue 10, pp. 7625-33, (2011) (PubMed).

Acharya, Lingenfelter, Huang, Gage, Walter: "Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells." in: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 34829-38, (2009) (PubMed).

Holmberg, Ingner, Johansson, Leander, Hjalt: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).

Lowry, Gould, Walter, Savage: "Absence of PITX2, BARX1, and FOXC1 mutations in De Hauwere syndrome (Axenfeld-Rieger anomaly, hydrocephaly, hearing loss): a 25-year follow up." in: American journal of medical genetics. Part A, Vol. 143A, Issue 11, pp. 1227-30, (2007) (PubMed).

Engenheiro, Saraiva, Carreira, Ramos, Ropers, Silva, Tommerup, Tümer: "Cytogenetically invisible microdeletions involving PITX2 in Rieger syndrome." in: Clinical genetics, Vol. 72, Issue 5, pp. 464-70, (2007) (PubMed).

Gudbjartsson, Arnar, Helgadottir, Gretarsdottir, Holm, Sigurdsson, Jonasdottir, Baker, Thorleifsson, Kristjansson, Palsson, Blondal, Sulem, Backman, Hardarson, Palsdottir, Helgason, Sigurjonsdottir et al.: "Variants conferring risk of atrial fibrillation on chromosome 4q25. ..." in: Nature, Vol. 448, Issue 7151, pp. 353-7, (2007) (PubMed).

Synonyms and alternative names related to PITX2

paired like homeodomain 2 (PITX2), paired-like homeodomain transcription factor 2 (Pitx2), paired-like homeodomain 2 (pitx2), paired-like homeodomain 2 (Pitx2), paired like homeodomain 2 S homeolog (pitx2.S), paired like homeodomain 2 (pitx2), paired like homeodomain 2 L homeolog (pitx2.L), paired like homeodomain 2 (Pitx2), 9430085M16Rik, ARP1, arp1, Brx1, brx1, Brx1a, Brx1b, IDG2, idg2, IGDS, igds, IGDS2, igds2, IHG2, ihg2, IRID2, irid2, Munc30, Otlx2, otlx2, pitx-2, pitx2, pitx2-A, Pitx2a, pitx2a, Pitx2b, Pitx2c, pitx2c, Pitx2cbeta, PTX2, Ptx2, ptx2, RGS, rgs, RIEG, Rieg, rieg, RIEG1, rieg1, RS, xpitx2, xPtx2, XPtx2b, zgc:110508

Protein level used designations for PITX2

  • ALL1-responsive protein ARP1
  • all1-responsive gene 1
  • homeobox protein PITX2
  • paired-like homeodomain transcription factor 2
  • pituitary homeobox 2
  • rieg bicoid-related homeobox transcription factor 1
  • solurshin
  • BRX1 homeoprotein
  • orthodenticle-like homeobox 2
  • paired-like homeodomain transcription factor Munc 30
  • paired-like homeodomain transcription factor 2a
  • pitx2b
  • homeodomain transcription factor 2
  • rPtx2
  • cPITX2
  • transcription factor Pitx2
  • homeodomain transcription factor Pitx2
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